Li JH, Yao RR, Shen HJ, Zhang L, Xie XY, Chen RX, Wang YH, Ren ZG. Clostridium perfringens infection after transarterial chemoembolization for large hepatocellular carcinoma. World J Gastroenterol 2015; 21(14): 4397-4401 [PMID: PMC4394104 DOI: 10.3748/wjg.v21.i14.4397]
Corresponding Author of This Article
Zheng-Gang Ren, PhD, Professor of Medicine, Liver Cancer Institute, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai 200032, China. renzhenggang@hotmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jing-Huan Li, Rong-Rong Yao, Hu-Jia Shen, Lan Zhang, Xiao-Ying Xie, Rong-Xin Chen, Yan-Hong Wang, Zheng-Gang Ren, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Author contributions: Li JH and Yao RR contributed equally to this work; Ren ZG designed the research; Li JH, Shen HJ, Yao RR, Zhang L, Xie XY, Chen RX and Wang YH collected the clinical data; Li JH and Yao RR wrote the paper.
Ethics approval: The study was reviewed and approved by the Ethnics Committee of Zhongshan Hospital, Fudan University.
Informed consent: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest: Authors declares no conflicting interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Zheng-Gang Ren, PhD, Professor of Medicine, Liver Cancer Institute, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai 200032, China. renzhenggang@hotmail.com
Telephone: +86-13681971302
Received: September 17, 2014 Peer-review started: September 18, 2014 First decision: December 2, 2014 Revised: January 28, 2015 Accepted: March 19, 2015 Article in press: March 19, 2015 Published online: April 14, 2015 Processing time: 209 Days and 17.7 Hours
Abstract
We report an unusual case of Clostridium perfringens liver abscess formation after transcatheter arterial chemoembolization (TACE) for large hepatocellular carcinoma. Severe deterioration in liver and renal function accompanied with hemocytolysis was found on the 2nd day after TACE. Blood culture found Clostridium perfringens and abdominal computed tomography revealed a gas-containing abscess in the liver. Following antibiotics administration and support care, the infection was controlled and the liver and renal function turned normal. The 2nd TACE procedure was performed 1.5 mo later and no recurrent Clostridium perfringens infection was found.
Core tip: Transcatheter arterial chemoembolization (TACE) is a major treatment for patients with hepatocellular carcinoma (HCC) that is not eligible for curative treatment. Though rare, Clostridium perfringens liver abscess after TACE is fatal. We successfully treated a 71-year-old man with large HCC who had liver and renal dysfunction and developed Clostridium perfringens liver abscess after TACE. After timely identification of the patient’s deteriorating condition, aggressive treatments, including antibiotics administration, anticoagulation and intensive care, were provided.
