Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.4101
Peer-review started: September 5, 2014
First decision: October 29, 2014
Revised: November 8, 2014
Accepted: December 14, 2014
Article in press: December 16, 2014
Published online: April 7, 2015
Processing time: 214 Days and 13.4 Hours
Folate deficiency and its association with cancer have been studied in the literature, but its clinical impact is still unknown. Folate deficiency and its result on gastric cancer is a mysterious part of oncology, with ongoing studies hopefully clarifying its impact on gastric cancer management. Lee et al studied folate deficiency and its impact on staging and clinical results. Here we try to contribute to the field by expressing our own thoughts about the paper.
Core tip: The analysis by Lee et al in the paper has some limitations that must be pointed out. The severity of folate deficiency, replacement strategies, and probable vitamin B12 deficiencies should have been discussed. The paper does not do enough to accurately conclude a relationship between folate deficiency and gastric cancer severity.