Jeong YS, Kim SE, Kwon MJ, Seo JY, Lim H, Park JW, Kang HS, Moon SH, Kim JH, Park CK. Signet-ring cell carcinoma arising from a fundic gland polyp in the stomach. World J Gastroenterol 2014; 20(47): 18044-18047 [PMID: 25548505 DOI: 10.3748/wjg.v20.i47.18044]
Corresponding Author of This Article
Sung Eun Kim, MD, Assistant Professor of Medicine, Department of Internal Medicine, University of Hallym College of Medicine, Hallym University Sacred Heart Hospital, 22, Gwanpyeong-ro 170-gil Dongan-gu, Anyang 431-796, South Korea. sekim@hallym.or.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
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World J Gastroenterol. Dec 21, 2014; 20(47): 18044-18047 Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.18044
Signet-ring cell carcinoma arising from a fundic gland polyp in the stomach
Yong Seol Jeong, Sung Eun Kim, Mi-Jung Kwon, Jae Yong Seo, Hyun Lim, Ji Won Park, Ho Suk Kang, Sung Hoon Moon, Jong Hyuk Kim, Choong Kee Park
Yong Seol Jeong, Sung Eun Kim, Jae Yong Seo, Hyun Lim, Ji Won Park, Ho Suk Kang, Sung Hoon Moon, Jong Hyuk Kim, Choong Kee Park, Department of Internal Medicine, University of Hallym College of Medicine, Hallym University Sacred Heart Hospital, Anyang 431-796, South Korea
Mi-Jung Kwon, Department of Pathology, University of Hallym College of Medicine, Hallym University Sacred Heart Hospital, Anyang 431-796, South Korea
Author contributions: Jeong YS wrote the manuscript; Kim SE performed the endoscopic procedures and advised on writing the manuscript; Kwon MJ diagnosed this case and provided the pathological interpretation; Seo JY, Lim H, Park JW, Kang HS, Moon SH, Kim JH and Park CK helped review the literature and provided critical advice for this work.
Correspondence to: Sung Eun Kim, MD, Assistant Professor of Medicine, Department of Internal Medicine, University of Hallym College of Medicine, Hallym University Sacred Heart Hospital, 22, Gwanpyeong-ro 170-gil Dongan-gu, Anyang 431-796, South Korea. sekim@hallym.or.kr
Telephone: +82-31-3803705 Fax: +82-31-3862269
Received: April 21, 2014 Revised: June 30, 2014 Accepted: July 29, 2014 Published online: December 21, 2014 Processing time: 243 Days and 4.9 Hours
Abstract
Fundic gland polyps (FGPs) are currently the most common type of gastric polyps and are usually benign. However, although rare, gastric adenocarcinoma of FGP has been recently proposed as a new variant of gastric adenocarcinoma. Here we report the first case of a 49-year-old woman with focal signet ring cell carcinoma that arose from an FGP of the stomach. The tumor was completely excised by endoscopic snare polypectomy. FGPs should therefore be evaluated for malignant changes although they occur rarely, if the FGP has an erosive or irregular surface.
Core tip: We report the first case of a 49-year-old woman diagnosed with focal signet ring cell carcinoma that arose from a fundic gland polyp in the stomach. The tumor was detected and completely excised by endoscopic snare polypectomy. Although malignant transformation of fundic gland polyps (FGPs) is extremely rare, endoscopists should consider the association of gastric polyps with gastric cancer for both hyperplastic polyps and FGPs.
