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World J Gastroenterol. Sep 21, 2014; 20(35): 12493-12500
Published online Sep 21, 2014. doi: 10.3748/wjg.v20.i35.12493
Current treatment options for colon cancer peritoneal carcinomatosis
Tomoyoshi Aoyagi, Krista P Terracina, Ali Raza, Kazuaki Takabe
Tomoyoshi Aoyagi, Krista P Terracina, Ali Raza, Kazuaki Takabe, Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298-0011, United States
Author contributions: All the authors generated the ideas and contributed to the writing of this paper.
Supported by NIH grants, No. R01CA160688 (to Takabe K) and No. T32CA085159-10 (to Terracina KP)
Correspondence to: Kazuaki Takabe, MD, PhD, FACS, Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine, West Hospital 7-402, 1200 East Broad Street, Richmond, VA 23298-0011, United States. ktakabe@vcu.edu
Telephone: +1-804-8289322 Fax: +1-804-8284808
Received: February 10, 2014
Revised: April 10, 2014
Accepted: June 2, 2014
Published online: September 21, 2014
Processing time: 221 Days and 19 Hours
Abstract

Peritoneal carcinomatosis (PC), the dissemination of cancer cells throughout the lining of the abdominal cavity, is the second most common presentation of colon cancer distant metastasis. Despite remarkable advances in cytotoxic chemotherapy and targeted therapy for colon cancer over the last 15 years, it has been repeatedly shown that these therapies remain ineffective for colon cancer PC. Recently, there has been a rapid accumulation of reports that cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) prolongs the life of colon cancer PC patients. Here, we will review the clinical presentation, the mechanisms of disease progression, and current treatment options for colon cancer PC, with a focus on the benefits and limitations of CRS-HIPEC.

Keywords: Cancer; Colorectal; Carcinomatosis; Peritoneal; Hyperthermic intraperitoneal chemotherapy; Intraperitoneal chemotherapy; Cytoreductive surgery; Mechanism

Core tip: This paper aims to review the clinical presentation, the mechanisms of disease progression, and current treatment options for colon cancer peritoneal carcinomatosis, with a focus on the benefits and limitations of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy.