Published online Jun 21, 2014. doi: 10.3748/wjg.v20.i23.7461
Revised: May 7, 2014
Accepted: May 19, 2014
Published online: June 21, 2014
Processing time: 75 Days and 2.2 Hours
AIM: To investigate the clinical significance of expression of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in ulcerative colitis (UC).
METHODS: Thirty UC specimens taken by colonoscopy from patients with active UC treated at the Department of Pathology, Central Hospital Affiliated to Shenyang Medical College from February 2010 to January 2012 were included in an experimental group, and 30 normal colon tissue samples taken by colonoscopy from non-UC patients were included in a control group. Expression of TF and TFPI in UC and normal colon tissue samples was detected by immunohistochemistry.
RESULTS: The positive rate of TF in UC was significantly higher than that in normal colon tissue (63% vs 33%, χ2 = 5.41, P < 0.05). The positive rate of TFPI in UC was also significantly higher than that in normal colon tissue (43% vs 17%, χ2 = 5.08, P < 0.05).
CONCLUSION: Positive rates of TF and TFPI expression in UC are significantly higher than those in normal colon tissue. TF and TFPI may play an important role in the pathogenesis of UC.
Core tip: Recent research showed that tissue factor (TF) and tissue factor pathway inhibitor (TFPI) are associated with inflammatory reactions, and they are expressed in many kinds of tissue and cells. There are few reports about the relationship between TF and TFPI and ulcerative colitis (UC). In this study, we performed immunohistochemical staining for TF and TFPI expression in tissue of UC and normal colon, to determine their association with UC and their significances in pathogenesis. The study results suggest that TF and TFPI may play an important role in the pathogenesis of UC.