Case Control Study
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World J Gastroenterol. Jun 14, 2014; 20(22): 6939-6945
Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.6939
Solid pseudopapillary tumor of the pancreas in male patients: Report of 16 cases
Yun-Qiang Cai, Si-Ming Xie, Xun Ran, Xing Wang, Gang Mai, Xu-Bao Liu
Yun-Qiang Cai, Si-Ming Xie, Xun Ran, Xing Wang, Gang Mai, Xu-Bao Liu, Department of Hepatopancreatobiliary Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Cai YQ and Liu XB designed the research; Cai YQ, Xie SM, Ran X, Wang X and Mai G performed the research and analyzed the data; Cai YQ and Xie SM wrote the paper; Liu XN and Mai G proofread and revised the manuscript; all authors approved the version to be published.
Supported by Special Fund of Ministry of Health for Medical Research in the Public Interest, No. 201202007
Correspondence to: Xu-Bao Liu, MD, Professor, Department of Hepatopancreatobiliary Surgery, West China Hospital, Sichuan University, No 37, Guo Xue Xiang, Chengdu, Sichuan Province, China. marsfriend@163.com
Telephone: +86-28-85422477 Fax:+86-28-85422474
Received: October 27, 2013
Revised: February 7, 2014
Accepted: March 4, 2014
Published online: June 14, 2014
Processing time: 232 Days and 5 Hours
Abstract

AIM: To investigate the clinical characteristics, surgical strategies and prognosis of solid pseudopapillary tumors (SPTs) of the pancreas in male patients.

METHODS: From July 2003 to March 2013, 116 patients were diagnosed with SPT of the pancreas in our institution. Of these patients, 16 were male. The patients were divided into two groups based on gender: female (group 1) and male (group 2). The groups were compared with regard to demographic characteristics, clinical presentations, surgical strategies, complications and follow-up outcomes.

RESULTS: Male patients were older than female patients (43.1 ± 12.3 years vs 33.1 ± 11.5 years, P = 0.04). Tumor size, location, and symptoms were comparable between the two groups. All patients, with the exception of one, underwent complete surgical resection. The patients were regularly followed up. The mean follow-up period was 58 mo. Two female patients (1.7%) developed tumor recurrence or metastases and required a second resection, and two female patients (1.7%) died during the follow-up period.

CONCLUSION: Male patients with SPT of the pancreas are older than female patients. There are no significant differences between male and female patients regarding surgical strategies and prognosis.

Keywords: Frantz tumor; Pancreas neoplasm; Solid pseudopapillary tumor

Core tip: Solid pseudopapillary tumor (SPT) of the pancreas is a rare tumor, with low-grade malignancy and a strong female preponderance. Male patients have been shown to have distinct patterns of onset and aggressiveness compared with female patients. However, this finding is controversial. This study included the largest number of male patients with SPT of the pancreas from a single institution and provided a better understanding of SPT in male patients.