Yan LH, Wei WY, Xie YB, Xiao Q. New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer. World J Gastroenterol 2014; 20(14): 3960-3966 [PMID: 24744585 DOI: 10.3748/wjg.v20.i14.3960]
Corresponding Author of This Article
Qiang Xiao, MD, PhD, Department of Surgery, the First Affiliated Hospital of Guangxi Medical University, No. 22, Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. xiaoqiang20050@aliyun.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 14, 2014; 20(14): 3960-3966 Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3960
New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer
Lin-Hai Yan, Wei-Yuan Wei, Yu-Bo Xie, Qiang Xiao
Lin-Hai Yan, Wei-Yuan Wei, Qiang Xiao, Department of Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Yu-Bo Xie, Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Xiao Q and Xie YB conceived and designed this review; Xiao Q and Xie YB contributed equally to this work; Wei WY performed the literature search; Yan LH and Wei WY analyzed the data; Yan LH and Wei WY wrote the paper; Yan LH and Wei WY are equal contributors.
Supported by The National Natural Science Foundation of China, No. 81060201; Natural Science Foundation of Guangxi Zhuang Autonomous Region of China, No. 2011GXNSFA018273 and No. 2013GXNSFAA019163; and the Key Health Science Fund of Guangxi Zhuang Autonomous Region of China, No. 1298003-2-6
Correspondence to: Qiang Xiao, MD, PhD, Department of Surgery, the First Affiliated Hospital of Guangxi Medical University, No. 22, Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. xiaoqiang20050@aliyun.com
Telephone: +86-771-5358325 Fax: +86-771-5358325
Received: September 26, 2013 Revised: December 22, 2013 Accepted: February 20, 2014 Published online: April 14, 2014 Processing time: 199 Days and 21.3 Hours
Abstract
Gastric cancer is one of the most frequent cancers, and it ranks the third most common cancer in China. The most recently caudal-related homeobox transcription factor 2 (CDX2) is expressed in a large number of human gastrointestinal cancers. In addition, gastric epithelial cell mutations in CDX2 result in tumor promotion, which is characterized by cellular drug resistance and a high proclivity for developing cancer. A series of publications over the past years suggests a mechanism by which CDX2 overexpression results in multidrug resistance. CDX2 appears to forward control regenerating IV and the multidrug resistance 1 expression signaling pathway for regulation of cell drug resistance.
Core tip: This review elucidates the relationship between caudal-related homeobox transcription factor 2 (CDX2) and gastric carcinoma, and promotes research to establish whether CDX2 induces drug resistance in gastric cancer. The review highlights that CDX2-positive expression should be a useful maker for diagnosis for patients with intestinal-phenotype gastric cancer, because of this useful maker, future drug and gene therapy targets in gastric cancer might be influenced.
