Effects of motility in gastric mucosal injuries induced by ethanol in rat

doi:10.3748/wjg.v2.iSuppl1.56

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Sep 15, 1996 (publication date) through Jan 12, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 1996; 2(Suppl1): 56-56
Published online Sep 15, 1996. doi: 10.3748/wjg.v2.iSuppl1.56

Effects of motility in gastric mucosal injuries induced by ethanol in rat

Xiao-Hua Hou, Jin-Song Liu, Wei Qian, Cui-Qiong Yi

Xiao-Hua Hou, Jin-Song Liu, Wei Qian, Cui-Qiong Yi, Union Hospital, Tongji Medical University, Wuhan 430022, Hubei Province, China

Author contributions: All authors contributed equally to the work.

Received: October 12, 1995
Revised: April 22, 1996
Accepted: August 13, 1996
Published online: September 15, 1996

Abstract

AIM: The effect of motility in gastric protection was rarely reported. We observed the muscosal injuries induced by ethanol in rats of ligated and non-ligated pylorus after giving cisapride.

METHODS: 2 rat groups: ligated and non-ligated pylorus group. Cisapride was given.

RESULTS: In non-ligated pylorus group, the ulcer index was decreased more remarkablly in high dose of cisapride than that in control, and the degree of damage was decreased in low and high doses of cisapride. In ligated pylorus group, the ulcer index and degree of damages were all larger than the non-ligated pylorus group, and the anti mucous damage function of cisapride disappeared.

CONCLUSION: This suggested normal gastric motor function has an important effect in cytoprotection. The effect of cisapride on gastric protection was via its prokinetic action.

Keywords: Motility; Gastric mucosal injuries; Ethanol; Rat