Cosme A, Montoro M, Santolaria S, Sanchez-Puertolas AB, Ponce M, Durán M, Cabriada JL, Borda N, Sarasqueta C, Bujanda L. Prognosis and follow-up of 135 patients with ischemic colitis over a five-year period. World J Gastroenterol 2013; 19(44): 8042-8046 [PMID: 24307798 DOI: 10.3748/wjg.v19.i44.8042]
Corresponding Author of This Article
Dr. Luis Bujanda, Department of Gastroenterology, Hospital de Donostia-Instituto Biodonostia, Centro de Investigaciones Biomédicas en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco UPV/EHU, Avda Paseo Beguiristain s/n, 20014 San Sebastián, Spain. medik@telefonica.net
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Brief Article
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World J Gastroenterol. Nov 28, 2013; 19(44): 8042-8046 Published online Nov 28, 2013. doi: 10.3748/wjg.v19.i44.8042
Prognosis and follow-up of 135 patients with ischemic colitis over a five-year period
Angel Cosme, Miguel Montoro, Santos Santolaria, Ana B Sanchez-Puertolas, Marta Ponce, Margarita Durán, Jose Luis Cabriada, Nerea Borda, Cristina Sarasqueta, Luis Bujanda
Angel Cosme, Nerea Borda, Luis Bujanda, Department of Gastroenterology, Hospital de Donostia-Instituto Biodonostia, Centro de Investigaciones Biomédicas en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco UPV/EHU, 20014 San Sebastián, Spain
Miguel Montoro, Santos Santolaria, Ana B Sanchez-Puertolas, Department of Gastroenterology, Hospital San Jorge, 22004 Huesca, Spain
Marta Ponce, Department of Gastroenterology, Hospital Universitari La Fé, 46026 Valencia, Spain
Margarita Durán, Jose Luis Cabriada, Department of Gastroenterology, Hospital de Galdakao, 48960 Bizcaia, Spain
Cristina Sarasqueta, Institute Biodonostia, CIBEResp, 20014 San Sebastián, Spain
Author contributions: Cosme A, Montoro M, Bujanda L developed the study concept and design and drafted the manuscript; Cosme A, Montoro M, Santolaria S, Sanchez-Puertolas AB, Ponce M, Durán M, Cabriada JL, Borda N, Bujanda L acquired the clinical data; Cosme A, Sarasqueta C carried out the statistical analysis of data and contributed to the analysis and interpretation of data; all authors performed a critical review and accept the final approval of the version to be published.
Correspondence to: Dr. Luis Bujanda, Department of Gastroenterology, Hospital de Donostia-Instituto Biodonostia, Centro de Investigaciones Biomédicas en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco UPV/EHU, Avda Paseo Beguiristain s/n, 20014 San Sebastián, Spain. medik@telefonica.net
Telephone: +34-943-007173 Fax: +34-943-007065
Received: May 30, 2013 Revised: August 14, 2013 Accepted: August 20, 2013 Published online: November 28, 2013 Processing time: 195 Days and 12.4 Hours
Abstract
AIM: To study the prognosis (recurrence and mortality) of patients with ischemic colitis (IC).
METHODS: This study was conducted in four Spanish hospitals, participants in the Ischemic Colitis in Spain study We analyzed prospectively 135 consecutive patients who met criteria for definitive or probable IC according to Brandt criteria, and follow up these patients during the next five years, retrospectively. Long-term results (recurrence and mortality) were evaluated retrospectively after a median interval of 62 mo (range 54-75 mo).
RESULTS: Estimated IC recurrence rates were 2.9%, 5.1%, 8.1% and 9.7% at years 1, 2, 3 and 5 years, respectively. Five-year survival was 69% (93 of 135) and 24% (10 of 42 patients) died for causes related to the IC. Among these 10 patients, 8 died in their first episode at hospital (4 had gangrenous colitis and 4 fulminant colitis) and 2 due to recurrence.
CONCLUSION: The five-year recurrence rate of IC was low. On the other hand, mortality during follow-up was high and was not associated with ischemic colitis.
Core tip: The prognosis of patients with ischemic colitis is unknown. In this study we observed that recurrence rate of ischemic colitis was low (9.7% at 5 years). However, the mortality was high (31% at 5 years) and the only factor associated with mortality was age.
