Li Z, Fang ZY, Ding Y, Yao WT, Yang Y, Zhu ZQ, Wang W, Zhang QX. Amplifications of NCOA3 gene in colorectal cancers in a Chinese population. World J Gastroenterol 2012; 18(8): 855-860 [PMID: 22371647 DOI: 10.3748/wjg.v18.i8.855]
Corresponding Author of This Article
Qin-Xian Zhang, Professor of Medicine, Chief, Department of Histology and Embryology, Basic Medical College of Zhengzhou University, Zhengzhou 450001, Henan Province, China. qx_zhang@sina.cn
Article-Type of This Article
Brief Article
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World J Gastroenterol. Feb 28, 2012; 18(8): 855-860 Published online Feb 28, 2012. doi: 10.3748/wjg.v18.i8.855
Amplifications of NCOA3 gene in colorectal cancers in a Chinese population
Zhi Li, Zheng-Yu Fang, Yi Ding, Wan-Tong Yao, Yang Yang, Zhong-Qing Zhu, Wen Wang, Qin-Xian Zhang
Zhi Li, Qin-Xian Zhang, Yi Ding, Department of Histology and Embryology, Basic Medical College of Zhengzhou University, Zhengzhou 450001, Henan Province, China
Zhi Li, Department of General Surgery, Henan Province Tumor Hospital, Zhengzhou 450001, Henan Province, China
Zheng-Yu Fang, Yang Yang, Zhong-Qing Zhu, Wen Wang, Biomedical Research Institute, Shenzhen-PKU-HKUST Medical Center, Shenzhen 518036, Guangdong Province, China
Wan-Tong Yao, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Author contributions: Li Z and Fang ZY contributed equally to this work; Li Z, Fang ZY and Zhang QX designed research; Li Z, Yang Y, Yao WT, Zhu ZQ, Wang W and Ding Y performed research; Fang ZY and Li Z analyzed data; Fang ZY and Zhang QX wrote the paper.
Supported by Fundamental Research Plan of Shenzhen City, No. JC201005260215A
Correspondence to: Qin-Xian Zhang, Professor of Medicine, Chief, Department of Histology and Embryology, Basic Medical College of Zhengzhou University, Zhengzhou 450001, Henan Province, China. qx_zhang@sina.cn
Telephone: +86-371-67781976 Fax: +86-371-67781976
Received: May 14, 2011 Revised: August 8, 2011 Accepted: August 31, 2011 Published online: February 28, 2012
Abstract
AIM: To investigate the copy number variation of NACO3 gene in colorectal cancer (CRC) and its correlation with tumor progression.
METHODS: A total of 142 samples of case-matched CRC tissues and adjacent normal tissues were obtained from patients undergoing bowel resection. Quantitative real-time polymerase chain reaction method was used to investigate the copy number variations of NCOA3 as well as gene expression in the collected tissues.
RESULTS: Copy number gains of NCOA3 were detected in 39 CRC samples (27.5%) and were correlated with tumor progression (χ2 = 6.42, P = 0.0112). Moreover, there was a positive correlation between copy number gain and mRNA over-expression of NCOA3 in CRCs (P = 0.0023). Expression level of NCOA3 mRNA was also enhanced in the CRC samples with unaltered copy numbers (3.85 ± 1.23 vs 2.71 ± 0.64, P < 0.01).
CONCLUSION: Sporadic colorectal cancers exhibit different mechanisms of NCOA3 regulation.
