Yan F, Gao YF, Lv F, Zhang TC, Li X, Yin HF. No association between IRF3 polymorphism and susceptibility to hepatitis B virus infection in Chinese patients. World J Gastroenterol 2012; 18(4): 388-392 [PMID: 22294846 DOI: 10.3748/wjg.v18.i4.388]
Corresponding Author of This Article
Hua-Fa Yin, Professor, Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei 230032, Anhui Province, China. yhf163.good@163.com
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Brief Article
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Fang Yan, Feng Lv, Xu Li, Hua-Fa Yin, Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China
Yu-Feng Gao, Department of Hepatopathy, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China
Tian-Chen Zhang, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui Province, China
Author contributions: Yan F and Gao YF contributed equally to this work; Zhang TC performed the data analysis; Yan F and Gao YF wrote the manuscript; Yan F, Gao YF and Lv F performed the majority of experiments; Gao YF and Yin HF designed the study; and Li X provided the financial support for this work.
Supported by Grants from the National Natural Science Foundation of China, No. 81072342; the National Pre-973 Program Projects, No. 2009CB526411
Correspondence to: Hua-Fa Yin, Professor, Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei 230032, Anhui Province, China. yhf163.good@163.com
Telephone: +86-551-2922912 Fax: +86-551-2922912
Received: April 25, 2011 Revised: July 28, 2011 Accepted: October 27, 2011 Published online: January 28, 2012
Abstract
AIM: To investigate the association between three tag single nucleotide polymorphisms (tagSNPs) in interferon regulatory factors (IRF3) and the genetic susceptibility to chronic hepatitis B virus (HBV) infection.
METHODS: We performed a case-control study of 985 Chinese cases of chronic HBV infection and 294 self-limiting HBV-infected individuals as controls. Three tagSNPs in IRF3 (rs10415576, rs2304204, rs2304206) were genotyped with the Multiplex SNaPshot technique. The genotype and allele frequencies were calculated and analyzed.
RESULTS: The three SNPs showed no significant genotype/allele associations with chronic HBV infection. Overall allele P values were: rs10415576, P = 0.0908, odds ratio (OR) [95% confidence interval (CI)] = 1.1798 (0.9740-1.4291); rs2304204, P = 0.5959, OR (95% CI) = 1.0597 (0.8552-1.3133); rs2304206, P = 0.8372, OR (95% CI) = 1.0250 (0.8097-1.2976). Overall genotype P values were: rs10415576, P = 0.2106; rs2304204, P = 0.8458; rs2304206, P = 0.8315. There were no statistically significant differences between patients with chronic HBV infection and controls. Haplotypes generated by these three SNPs were also not significantly different between the two groups.
CONCLUSION: The three tagSNPs of IRF3 are not associated with HBV infection in the Han Chinese population.
Yan F, Gao YF, Lv F, Zhang TC, Li X, Yin HF. No association between IRF3 polymorphism and susceptibility to hepatitis B virus infection in Chinese patients. World J Gastroenterol 2012; 18(4): 388-392 [PMID: 22294846 DOI: 10.3748/wjg.v18.i4.388]
