Brief Article
Copyright ©2012 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jun 21, 2012; 18(23): 3015-3019
Published online Jun 21, 2012. doi: 10.3748/wjg.v18.i23.3015
Analysis of risk factors for polypoid lesions of gallbladder among health examinees
Hua-Li Yang, Lei Kong, Li-Li Hou, Hui-Fang Shen, Yu Wang, Xin-Gang Gu, Jian-Min Qin, Pei-Hao Yin, Qi Li
Hua-Li Yang, Hui-Fang Shen, Yu Wang, Xin-Gang Gu, Department of Ultrasonography, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
Lei Kong, Li-Li Hou, Jian-Min Qin, Pei-Hao Yin, Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
Qi Li, Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
Author contributions: Yang HL and Kong L contributed equally to this work; Yang HL, Kong L, Gu XG, Yin PH and Li Q designed and supervised the study; Kong L, Hou LL, Shen HF, Wang Y, Gu XG and Qin JM performed the experiments; Yang HL, Kong L and Yin PH wrote the manuscript; and all authors read and approved the final version to be published.
Correspondence to: Dr. Pei-Hao Yin, MD, Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No. 164, Lanxi Road, Shanghai 200062, China. yinpeihao1975@hotmail.com
Telephone: +86-21-62572723 Fax: +86-21-52665957
Received: January 28, 2012
Revised: March 20, 2012
Accepted: April 9, 2012
Published online: June 21, 2012
Abstract

AIM: To investigate the prevalence and risk factors of polypoid lesions of gallbladder (PLG) among the health examinees in the Shanghai region, China.

METHODS: A total of 11 816 subjects who underwent health examinations in our hospital between August 2010 and February 2011 were analyzed retrospectively. Among them, there were 7174 men and 4642 women. PLG was diagnosed by the real-time ultrasonography. Those with the body mass index (BMI) ≥ 28 were considered to be obese. Blood biochemical indices were detected with the fully automatic biochemical analyzer and hepatitis B surface antigen (HBsAg) was tested by the automated enzyme immunoassay. The correlations between the prevalence of PLG and age, sex, BMI, serum cholesterol (T-Cho), triglycerides (TG), blood sugar, HBsAg, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), gallstone and fatty liver were investigated. After univariate analysis of 11 variables, stepwise logistic regression analysis was performed to explore the risk factors of PLG.

RESULTS: There was a significant difference in sex, T-Cho, HBsAg, HDL-C, LDL-C and fatty liver between the PLG-positive group and the PLG-negative group (332/163 vs 6842/4479, P = 0.003; 22/473 vs 295/11 026, P =0.013; 92/403 vs 993/10 328, P = 0.001; 47/448 vs 332/10 989, P = 0.001; 32/463 vs 381/10 940, P = 0.001; 83/412 vs 3260/8061, P = 0.001). No significant difference was found in the age, BMI, TG, blood sugar and gallstone between the two groups (47.3 ± 26 vs 45.1 ± 33, P = 0.173; 59/436 vs 1097/10 224, P = 0.102; 52/443 vs 982/10 339, P = 0.158; 17/478 vs 295/11 026, P = 0.26; 24/471 vs 395/10 926, P = 0.109). Logistic regression analysis showed that the sex, HBsAg and HDL-C were independent risk factors for the development of PLG in a descending order of HDL-C > HBsAg > sex.

CONCLUSION: In healthy people, the male gender, positive HBsAg, and low HDL-C confer higher risks of PLG development.

Keywords: Polypoid; Gallbladder; Risk factors; Ultrasonography; Health examination