Park CH, Jeong SH, Yim HW, Kim JD, Bae SH, Choi JY, Yoon SK. Family history influences the early onset of hepatocellular carcinoma. World J Gastroenterol 2012; 18(21): 2661-2667 [PMID: 22690075 DOI: 10.3748/wjg.v18.i21.2661]
Corresponding Author of This Article
Seung Kew Yoon, MD, PhD, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, No. 505, Banpo-Dong, Seocho-Gu, Seoul 137-701, South Korea. yoonsk@catholic.ac.kr
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World J Gastroenterol. Jun 7, 2012; 18(21): 2661-2667 Published online Jun 7, 2012. doi: 10.3748/wjg.v18.i21.2661
Family history influences the early onset of hepatocellular carcinoma
Chung-Hwa Park, Seung-Hee Jeong, Hyeon-Woo Yim, Jin Dong Kim, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon
Chung-Hwa Park, Jin Dong Kim, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Department of Internal Medicine, The Catholic University of Korea, Seoul 137-701, South Korea
Seung-Hee Jeong, Hyeon-Woo Yim, Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea
Seung-Hee Jeong, Hyeon-Woo Yim, Clinical Research Coordinating Center of Catholic Medical Center, The Catholic University of Korea, Seoul 137-701, South Korea
Author contributions: Park CH contributed in designing the study, wrote the manuscript and participated in the statistical analysis; Jeong SH contributed in the majority of the statistical analysis; Yim HW co-ordinated and supported the statistical analysis; Kim JD, Bae SH and Choi JY provided the collection of all the data, analytical tools, and were involved in editing the manuscript; Yoon SK designed and co-ordinated the whole study, mainly edited the manuscript and provided the financial support.
Supported by Nuclear R and D Program of the Ministry of Science and Technology, South Korea, No. 2010-0017595; and a grant from the Korea Health 21 R and D Project, No. A070001, Ministry of Health and Welfare, South Korea
Correspondence to: Seung Kew Yoon, MD, PhD, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, No. 505, Banpo-Dong, Seocho-Gu, Seoul 137-701, South Korea. yoonsk@catholic.ac.kr
Telephone: +82-2-22587534 Fax: +82-2-34814025
Received: October 5, 2011 Revised: December 19, 2011 Accepted: April 28, 2012 Published online: June 7, 2012
Abstract
AIM: To evaluate the relationship between a positive family history of primary liver cancer and hepatocellular carcinoma (HCC) development in Korean HCC patients.
METHODS: We studied a total of 2242 patients diagnosed with HCC between January 1990 and July 2008, whose family history of primary liver cancer was clearly described in the medical records.
RESULTS: Of the 2242 patients, 165 (7.4%) had a positive family history of HCC and 2077 (92.6%) did not. The male to female ratio was 3.6:1, and the major causes of HCC were chronic hepatitis B virus (HBV) infection in 75.1%, chronic hepatitis C virus infection in 13.2% and alcohol in 3.1%. The median ages at diagnosis in the positive- and negative-history groups were 52 years (range: 29-79 years) and 57 years (range: 18-89 years), respectively (P < 0.0001). Furthermore, among 1713 HCC patients with HBV infection, the number of patients under 45 years of age out of 136 patients with positive family history was 26 (19.1%), whereas those out of 1577 patients with negative family history was 197 (12.5%), suggesting that a positive family history may be associated with earlier development of HCC in the Korean population (P = 0.0028).
CONCLUSION: More intensive surveillance maybe recommended to those with a positive family history of HCC for earlier diagnosis and proper management especially when HBV infection is present.
Park CH, Jeong SH, Yim HW, Kim JD, Bae SH, Choi JY, Yoon SK. Family history influences the early onset of hepatocellular carcinoma. World J Gastroenterol 2012; 18(21): 2661-2667 [PMID: 22690075 DOI: 10.3748/wjg.v18.i21.2661]
