Brief Article
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World J Gastroenterol. Mar 21, 2012; 18(11): 1262-1269
Published online Mar 21, 2012. doi: 10.3748/wjg.v18.i11.1262
Gastric cancer incidence and mortality in Zhuanghe, China, between 2005 and 2010
Jing-Jing Jing, Hui-Yuan Liu, Jin-Kuan Hao, Li-Na Wang, Yun-Ping Wang, Li-Hua Sun, Yuan Yuan
Jing-Jing Jing, Yuan Yuan, Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Key Laboratory of Cancer Control in Liaoning Province, Shenyang 110001, Liaoning Province, China
Hui-Yuan Liu, Jin-Kuan Hao, Li-Na Wang, Yun-Ping Wang, The Center of Disease Prevention and Control, Zhuanghe 116400, Liaoning Province, China
Li-Hua Sun, Office for Cancer Prevention and Control and Cancer Registry of Liaoning Province, Shenyang 110001, Liaoning Province, China
Author contributions: Jing JJ performed data interpretation and statistical analysis and wrote the paper; Liu HY, Hao JK, Wang LN and Wang YP collected the data; Sun LH was in charge of quality control during the period of data collection; and Yuan Y conceived and designed this study and revised the manuscript.
Supported by Grants from the Tenth Five-Year Program for National Scientific Key Project of China, No. 2004BA703B06-2; 973 National Basic Research Development Program of China, No. 2010CB529304; and the funds for scientific research from the Financial Department of Liaoning Province, China, No. 2008-621
Correspondence to: Yuan Yuan, Professor, Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, Liaoning Province, China. yyuan@mail.cmu.edu.cn
Telephone: +86-24-83282153 Fax: +86-24-83282292
Received: May 18, 2011
Revised: July 28, 2011
Accepted: August 15, 2011
Published online: March 21, 2012
Abstract

AIM: To investigate the incidence and mortality of gastric cancer (GC) in Zhuanghe region, northeast China and the influencing factors for their changing trends.

METHODS: All new cancer cases and deaths registered from 2005 to 2010 in Zhuanghe County were reviewed. The annual GC cases, constituent ratio, crude rates, age-standardized rates, their sex and age distribution and temporal trends were assessed. The method of annual percentage change (APC) was used to estimate the trends of GC.

RESULTS: Altogether 2634 new cases of GC and 1722 related deaths were registered, which accounted for 21.04% and 19.13% of all cancer-related incidence and deaths, respectively. The age-standardized incidence rate steadily decreased from 57.48 in 2005 to 44.53 in 2010 per 105 males, and from 18.13 to 14.70 per 105 females, resulting in a APC of -5.81% for males and -2.89% for females over the entire period. The magnitude of APC in GC mortality amounted to -11.09% and -15.23%, respectively, as the age-standardized mortality rate steadily decreased from 42.08 in 2005 to 23.71 in 2010 per 105 males, and from 23.86 to 10.78 per 105 females. Females had a significantly lower incidence (a male/female ratio 2.80, P < 0.001) and mortality (a male/female ratio 2.30, P < 0.001). In both genders, the peak incidence and mortality occurred in the 80-84 years age group. The age-standardized mortality/incidence ratio also decreased from the peak of 0.73 in 2005 to 0.53 in 2010 for males, and from 1.32 to 0.73 for females.

CONCLUSION: Encouraging declines of incidence and mortality of GC were observed in Zhuanghe region between 2005 and 2010, possibly due to the economic development and efficient GC control strategies.

Keywords: Gastric cancer; Incidence; Mortality; Trend; High-risk areas