Araújo AP, Costa BM, Pinto-Correia AL, Fragoso M, Ferreira P, Dinis-Ribeiro M, Costa S, Reis RM, Medeiros R. Association between EGF +61A/G polymorphism and gastric cancer in Caucasians. World J Gastroenterol 2011; 17(4): 488-492 [PMID: 21274378 DOI: 10.3748/wjg.v17.i4.488]
Corresponding Author of This Article
Rui Medeiros, Professor, Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Edifício Laboratórios-PISO 4, Rua. Dr Ant. Bernardino Almeida, 4200-072 Porto, Portugal. ruimedei@ipoporto.min-saude.pt
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World J Gastroenterol. Jan 28, 2011; 17(4): 488-492 Published online Jan 28, 2011. doi: 10.3748/wjg.v17.i4.488
Association between EGF +61A/G polymorphism and gastric cancer in Caucasians
Ana Paula Araújo, Bruno M Costa, Ana L Pinto-Correia, Maria Fragoso, Paula Ferreira, Mário Dinis-Ribeiro, Sandra Costa, Rui M Reis, Rui Medeiros
Ana Paula Araújo, Ana L Pinto-Correia, Paula Ferreira, Rui Medeiros, Molecular Oncology Group, Portuguese Institute of Oncology of Porto, 4200-072 Porto, Portugal
Bruno M Costa, Sandra Costa, Rui M Reis, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, 4704-553 Braga, Portugal
Maria Fragoso, Oncology Department, Portuguese Institute of Oncology of Porto, 4200-072 Porto, Portugal
Mário Dinis-Ribeiro, Gastroenterology Department, Portuguese Institute of Oncology of Porto, Portugal; and Cintesis/Faculty of Medicine University of Porto, 4200-072 Porto, Portugal
Rui Medeiros, Centro de Estudos em Biomedicina, Health Sciences Faculty-Fernando Pessoa University, 4200-150 Porto, Portugal
Rui Medeiros, Instituto de Ciencias Biomédicas de Abel Salazar, Abel Salazar Institute for the Biomedical Sciences, 4099-003 Porto, Portugal
Author contributions: Araújo AP, Costa BM, Costa S performed the research; Araújo AP and Medeiros R wrote the paper; Fragoso M and Ferreira P identified and diagnosed the patients; Medeiros R and Dinis-Ribeiro M designed, supervised and participated in the editing of the manuscript; all authors read and approved the final manuscript.
Supported by The Portuguese League Against Cancer (Liga Portuguesa Contra o Cancro-Núcleo Regional do Norte) and AstraZeneca Foundation
Correspondence to: Rui Medeiros, Professor, Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Edifício Laboratórios-PISO 4, Rua. Dr Ant. Bernardino Almeida, 4200-072 Porto, Portugal. ruimedei@ipoporto.min-saude.pt
Telephone: +351-22-5084000 Fax: + 351-22-5084001
Received: January 26, 2010 Revised: April 30, 2010 Accepted: May 7, 2010 Published online: January 28, 2011
Abstract
AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study.
METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian.
RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021).
CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men.
