Huang K, Hu JH, Wang HF, He WP, Chen J, Duan XZ, Zhang AM, Liu XY. Survival and prognostic factors in hepatitis B virus-related acute-on-chronic liver failure. World J Gastroenterol 2011; 17(29): 3448-3452 [PMID: 21876637 DOI: 10.3748/wjg.v17.i29.3448]
Corresponding Author of This Article
Jin-Hua Hu, Associate Professor, Liver Failure Treatment and Research Center, 302 Military Hospital, Beijing 100039, China. hjh@medmail.com.cn
Article-Type of This Article
Brief Article
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World J Gastroenterol. Aug 7, 2011; 17(29): 3448-3452 Published online Aug 7, 2011. doi: 10.3748/wjg.v17.i29.3448
Survival and prognostic factors in hepatitis B virus-related acute-on-chronic liver failure
Kun Huang, Jin-Hua Hu, Hui-Fen Wang, Wei-Ping He, Jing Chen, Xue-Zhang Duan, Ai-Min Zhang, Xiao-Yan Liu
Kun Huang, Jin-Hua Hu, Liver Failure Treatment and Research Center, 302 Military Hospital, Peking University Health Science Center, Beijing 100191, China
Jin-Hua Hu, Hui-Fen Wang, Wei-Ping He, Jing Chen, Xue-Zhang Duan, Ai-Min Zhang, Xiao-Yan Liu, Liver Failure Treatment and Research Center, 302 Military Hospital, Beijing 100039, China
Author contributions: Huang K analyzed the data; Huang K and Hu JH wrote the paper; Hu JH and Wang HF designed the study; Huang K, He WP, Chen J, Duan XZ, Zhang AM and Liu XY collected the data and performed the study.
Supported by National 11th Five-Year Special Major Project for Infectious Diseases (No. 2008zx10002-005-6); Collaborative Project between US and China on Major Liver Diseases (No. 2009DFA32450); The Capital Medical Research and Development (No. 20072026); the Army Medical and Health Scientific Research Fund of China, No. 06H057
Correspondence to: Jin-Hua Hu, Associate Professor, Liver Failure Treatment and Research Center, 302 Military Hospital, Beijing 100039, China. hjh@medmail.com.cn
Telephone: +86-10-66933434 Fax: +86-10-63879339
Received: October 7, 2010 Revised: November 8, 2010 Accepted: November 15, 2010 Published online: August 7, 2011
Abstract
AIM: To investigate the survival rates and prognostic factors in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF).
METHODS: Clinical data in hospitalized patients with HBV-ACLF admitted from 2006 to 2009 were retrospectively analyzed. Their general conditions and survival were analyzed by survival analysis and Cox regression analysis.
RESULTS: A total of 190 patients were included in this study. The overall 1-year survival rate was 57.6%. Patients not treated with antiviral drugs had a significantly higher mortality [relative risk (RR) = 0.609, P = 0.014]. The highest risk of death in patients with ACLF was associated with hepatorenal syndrome (HRS) (RR = 2.084, P =0.026), while other significant factors were electrolyte disturbances (RR = 2.062, P = 0.010), and hepatic encephalopathy (HE) (RR = 1.879, P < 0.001).
CONCLUSION: Antiviral therapy has a strong effect on the prognosis of the patients with HBV-ACLF by improving their 1-year survival rate. HRS, electrolyte disturbances, and HE also affect patient survival.
Huang K, Hu JH, Wang HF, He WP, Chen J, Duan XZ, Zhang AM, Liu XY. Survival and prognostic factors in hepatitis B virus-related acute-on-chronic liver failure. World J Gastroenterol 2011; 17(29): 3448-3452 [PMID: 21876637 DOI: 10.3748/wjg.v17.i29.3448]
