Dong QM, Zhang JQ, Li Q, Bracher JC, Hendricks DT, Zhao XH. Clinical significance of serum expression of GROβ in esophageal squamous cell carcinoma. World J Gastroenterol 2011; 17(21): 2658-2662 [PMID: 21677836 DOI: 10.3748/wjg.v17.i21.2658]
Corresponding Author of This Article
Dr. Xiao-Hang Zhao, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. zhaoxh@cicams.an.cn
Article-Type of This Article
Brief Article
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World J Gastroenterol. Jun 7, 2011; 17(21): 2658-2662 Published online Jun 7, 2011. doi: 10.3748/wjg.v17.i21.2658
Clinical significance of serum expression of GROβ in esophageal squamous cell carcinoma
Qiao-Mei Dong, Jin-Qiang Zhang, Qian Li, Jacqueline C Bracher, Denver T Hendricks, Xiao-Hang Zhao
Qiao-Mei Dong, Jin-Qiang Zhang, Qian Li, Xiao-Hang Zhao, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Xiao-Hang Zhao, Center of Basic Medical Sciences, Navy General Hospital, Beijing 100048, China
Denver T Hendricks, Jacqueline C Bracher, Division of Medical Biochemistry, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa
Author contributions: Dong QM, Zhang JQ, Li Q performed the majority of experiments; Dong QM and Bracher JC analyzed the data and drafted the manuscript; Zhao XH designed the study, discussed and revised the manuscript with Hendricks DT.
Supported by The Grants from International Science & Technology Cooperation and Exchange Programs, No. 2008DFA31130; Joint China/South Africa Science and Technology Agreement; National Natural Science Foundation of China, No. 81021061, No. 0772507 and No. 30700992; State Key Projects for Basic Research of China, No. 2011CB910703
Correspondence to: Dr. Xiao-Hang Zhao, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. zhaoxh@cicams.an.cn
Telephone: +86-10-67709015 Fax: +86-10-87778360
Received: January 20, 2011 Revised: April 6, 2011 Accepted: April 13, 2011 Published online: June 7, 2011
Abstract
AIM: To determine the association between serum levels of growth-related gene product β (GROβ) and clinical parameters in esophageal squamous cell carcinoma (ESCC).
METHODS: Using enzyme-linked immunosorbent assay, serum GROβ levels were measured in ESCC patients (n = 72) and healthy volunteers (n = 83). The association between serum levels of GROβ and clinical parameters of ESCC was analyzed statistically.
RESULTS: The serum GROβ levels were much higher in ESCC patients than in healthy controls (median: 645 ng/L vs 269 ng/L, P < 0.05). Serum GROβ levels were correlated positively with tumor size, lymph node metastasis, and tumor-node-metastasis (TNM) staging, but not with gender or the histological grade of tumors in ESCC patients. The sensitivity and specificity of the assay for serum GROβ were 73.61% and 56.63%, respectively.
CONCLUSION: GROβ may function as an oncogene product and contribute to tumorigenesis and metastasis of ESCC.
