Brief Article
Copyright ©2011 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jan 14, 2011; 17(2): 260-266
Published online Jan 14, 2011. doi: 10.3748/wjg.v17.i2.260
CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: A meta-analysis
Jian-Qiang Jin, Yuan-Yuan Hu, Yu-Ming Niu, Gong-Li Yang, Yu-Yu Wu, Wei-Dong Leng, Ling-Yun Xia
Jian-Qiang Jin, Yu-Yu Wu, Department of Pathology, Affiliated No. 4 Hospital of Soochow University, Wuxi 214062, Jiangsu Province, China
Yuan-Yuan Hu, Yu-Ming Niu, Wei-Dong Leng, Ling-Yun Xia, Department of Stomatology, Affiliated Taihe Hospital of Hubei University of Medicine, Shiyan 442000, Hubei Province, China
Gong-Li Yang, Department of Gastroenterology, Affiliated Taihe Hospital of Hubei University of Medicine, Shiyan 442000, Hubei Province, China
Author contributions: Jin JQ and Hu YY contributed equally to this work; Jin JQ and Hu YY searched and analyzed the literature; Niu YM, Yang GL and Xia LY revised the manuscript; Wu YY and Leng WD provided the idea of this study.
Correspondence to: Yu-Yu Wu, Associate Professor, Department of Pathology, Affiliated No.4 Hospital of Soochow University, 200 Huihe Road, Wuxi 214062, Jiangsu Province, China. jinjianqiang2010@yeah.net
Telephone: +86-510-88683076 Fax: +86-510-85808820
Received: September 4, 2010
Revised: October 16, 2010
Accepted: October 23, 2010
Published online: January 14, 2011
Abstract

AIM: To study the relation between CYP1A1 Ile462Val polymorphism and colorectal cancer risk by meta-analysis.

METHODS: A meta-analysis was performed to investigate the relation between CYP1A1 Ile462Val polymorphism and colorectal cancer risk by reviewing the related studies until September 2010. Data were extracted and analyzed. Crude odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of relation between CYP1A1 Ile462Val polymorphism and colorectal cancer risk.

RESULTS: Thirteen published case-control studies including 5336 cases and 6226 controls were acquired. The pooled OR with 95% CI indicated that CYP1A1 Ile462Val polymorphism was significantly related with colorectal cancer risk (Val/Val vs Ile/Ile: OR = 1.47, 95% CI: 1.16-1.86, P = 0.002; dominant model: OR = 1.33, 95% CI: 1.01-1.75, P = 0.04; recessive model: OR = 1.49, 95% CI: 1.18-1.88, P = 0.0009). Subgroup ethnicity analysis showed that CYP1A1 Ile462Val polymorphism was also significantly related with colorectal cancer risk in Europeans (Ile/Val vs Ile/Ile: OR = 1.22, 95% CI: 1.05-1.42, P = 0.008; dominant model: OR = 1.24, 95% CI: 1.07-1.43, P = 0.004) and Asians (Val/Val vs Ile/Ile: OR = 1.40, 95% CI: 1.07-1.82, P = 0.01; recessive model: OR = 1.46, 95% CI: 1.12-1.89, P = 0.005).

CONCLUSION: CYP1A1 Ile462Val may be an increased risk factor for colorectal cancer.

Keywords: CYP1A1; Polymorphism; Colorectal cancer; Meta-analysis