Brief Article
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World J Gastroenterol. May 14, 2011; 17(18): 2343-2348
Published online May 14, 2011. doi: 10.3748/wjg.v17.i18.2343
XPD Lys751Gln polymorphism and esophageal cancer risk: A meta-analysis involving 2288 cases and 4096 controls
Ling Yuan, Dan Cui, Er-Jiang Zhao, Chen-Zhi Jia, Li-Dong Wang, Wei-Quan Lu
Ling Yuan, Department of Gastroenterology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China
Ling Yuan, Department of Radiotherapy, Henan Tumor Hospital and Institute, Zhengzhou 450003, Henan Province, China
Dan Cui, Wei-Quan Lu, Department of Epidemiology, Henan Tumor Institute, Zhengzhou 450003, Henan Province, China
Dan Cui, Er-Jiang Zhao, Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China
Chen-Zhi Jia, Department of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China
Li-Dong Wang, Henan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital, College of Basic Medicine, Zhengzhou University, Zhengzhou 450052, Henan Province, China
Author contributions: Yuan L, Cui D, Wang LD and Lu WQ designed the research; Yuan L, Lu WQ, Wang LD and Jia CZ performed the research; Yuan L, Cui D and Zhao EJ wrote the paper.
Correspondence to: Li-Dong Wang, Professor, Henan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital, College of Basic Medicine, Zhengzhou University, Zhengzhou 450052, Henan Province, China. ldwang2007@126.com
Telephone: +86-371-66658335 Fax: +86-371-66658335
Received: September 16, 2010
Revised: December 21, 2010
Accepted: December 28, 2010
Published online: May 14, 2011
Abstract

AIM: To evaluate the association between xeroderma pigmentosum group D (XPD), genetic polymorphism Lys751Gln and esophageal cancer risk.

METHODS: We searched PubMed up to September 1, 2010 to identify eligible studies. A total of 10 case-control studies including 2288 cases and 4096 controls were included in the meta-analysis. Statistical analysis was performed with Review Manage version 4.2. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association.

RESULTS: The results suggested that there is no significant association between XPD Lys751Gln polymorphism and esophageal cancer susceptibility in the overall population. However, in subgroup analysis by histology type, a significant association was found between XPD Lys751Gln polymorphism and esophageal adenocarcinoma (for CC vs AA: OR = 1.25, 95% CI = 1.01-1.55, P = 0.05 for heterogeneity).

CONCLUSION: Our meta-analysis suggested that XPD Lys751Gln polymorphism may be associated with increased risk of esophageal adenocarcinoma.

Keywords: Xeroderma pigmentosum group D; Polymorphism; Esophageal cancer; Mwta-analysis