Yoshida K, Furuta K, Adachi K, Ohara S, Morita T, Tanimura T, Nakata S, Miki M, Koshino K, Kinoshita Y. Effects of anti-hypertensive drugs on esophageal body contraction. World J Gastroenterol 2010; 16(8): 987-991 [PMID: 20180238 DOI: 10.3748/wjg.v16.i8.987]
Corresponding Author of This Article
Kenji Furuta, MD, PhD, Second Department of Internal Medicine, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo-shi, Shimane 693-8501, Japan. kfuruta@med.shimane-u.ac.jp
Article-Type of This Article
Brief Article
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Koichi Yoshida, Kenji Furuta, Shunji Ohara, Terumi Morita, Takashi Tanimura, Shuji Nakata, Masaharu Miki, Kenji Koshino, Yoshikazu Kinoshita, Second Department of Internal Medicine, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo-shi, Shimane 693-8501, Japan
Kyoichi Adachi, Department of Clinical Nursing, Shimane University Faculty of Medicine, Enya-cho, Izumo-shi, Shimane 693-8501, Japan
Author contributions: Yoshida K and Furuta K contributed equally to this work; Yoshida K, Furuta K, Adachi K and Kinoshita Y designed the research; Yoshida K, Furuta K, Adachi K, Ohara S, Morita T, Tanimura T, Nakata S, Miki M, Koshino K and Kinoshita Y performed the research; Yoshida K, Furuta K, Adachi K and Kinoshita Y analyzed the data and wrote the manuscript.
Supported by The Grants-in-Aid from Science Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan, No. 19590724
Correspondence to: Kenji Furuta, MD, PhD, Second Department of Internal Medicine, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo-shi, Shimane 693-8501, Japan. kfuruta@med.shimane-u.ac.jp
Telephone: +81-853-202190 Fax: +81-853-202187
Received: October 29, 2009 Revised: December 9, 2009 Accepted: December 16, 2009 Published online: February 28, 2010
Abstract
AIM: To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possible relationship with gastro-esophageal reflux disease.
METHODS: Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine, losartan, and atenolol, as well as without any drug administration.
RESULTS: Peristaltic contractions by the esophageal body were separated into three segments by two troughs. The peak peristaltic pressures in the mid and lower segments of the esophageal body under atenolol administration were significantly higher than those without medication in a supine position. On the other hand, peristaltic pressures under nifedipine administration were lower than those observed without drug administration. Losartan did not change esophageal body peristalsis. Atenolol elevated LES pressure and slowed peristaltic wave transition, while the effects of nifedipine were the opposite.
CONCLUSION: Among the anti-hypertensive drugs tested, atenolol enhanced esophageal motor activity, which was in contrast to nifedipine.
