Ha HL, Shin HJ, Feitelson MA, Yu DY. Oxidative stress and antioxidants in hepatic pathogenesis. World J Gastroenterol 2010; 16(48): 6035-6043 [PMID: 21182217 DOI: 10.3748/wjg.v16.i48.6035]
Corresponding Author of This Article
Dae-Yeul Yu, PhD, Disease Model Research Laboratory, Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Oun-dong, Yuseong-gu, Daejeon 305-806, South Korea. dyyu10@kribb.re.kr
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Editorial
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World J Gastroenterol. Dec 28, 2010; 16(48): 6035-6043 Published online Dec 28, 2010. doi: 10.3748/wjg.v16.i48.6035
Oxidative stress and antioxidants in hepatic pathogenesis
Hye-Lin Ha, Hye-Jun Shin, Mark A Feitelson, Dae-Yeul Yu
Hye-Lin Ha, Hye-Jun Shin, Dae-Yeul Yu, Disease Model Research Laboratory, Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, South Korea
Hye-Lin Ha, Dae-Yeul Yu, Department of Functional Genomics, University of Science and Technology, Daejeon 305-333, South Korea
Mark A Feitelson, Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, United States
Author contributions: Ha HL and Yu DY designed the research; Ha HL and Shin HJ performed the research; Ha HL, Feitelson MA and Yu DY wrote the paper.
Supported by The 21st Century Frontier Program in the Functional Human Genome Project, No. HGM0200934; the International Collaboration Program of Science and Technology, No. FGM0600914; the Ministry of Education, Science and Technology, and the KRIBB Research Initiative Program Grant, No. KGM3320911, South Korea
Correspondence to: Dae-Yeul Yu, PhD, Disease Model Research Laboratory, Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Oun-dong, Yuseong-gu, Daejeon 305-806, South Korea. dyyu10@kribb.re.kr
Telephone: +82-42-8604422 Fax: +82-42-8604609
Received: June 2, 2010 Revised: July 12, 2010 Accepted: July 19, 2010 Published online: December 28, 2010
Abstract
Long term hepatitis B virus (HBV) infection is a major risk factor in pathogenesis of chronic liver diseases, including hepatocellular carcinoma (HCC). The HBV encoded proteins, hepatitis B virus X protein and preS, appear to contribute importantly to the pathogenesis of HCC. Both are associated with oxidative stress, which can damage cellular molecules like lipids, proteins, and DNA during chronic infection. Chronic alcohol use is another important factor that contributes to oxidative stress in the liver. Previous studies reported that treatment with antioxidants, such as curcumin, silymarin, green tea, and vitamins C and E, can protect DNA from damage and regulate liver pathogenesis-related cascades by reducing reactive oxygen species. This review summarizes some of the relationships between oxidative stress and liver pathogenesis, focusing upon HBV and alcohol, and suggests antioxidant therapeutic approaches.
