Ma F, Chen Y, Li J, Qing HP, Wang JD, Zhang YL, Long BG, Bai Y. Screening test for anti-Helicobacter pylori activity of traditional Chinese herbal medicines. World J Gastroenterol 2010; 16(44): 5629-5634 [PMID: 21105198 DOI: 10.3748/wjg.v16.i44.5629]
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Dr. Yang Bai, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Tonghe Road 1838, Guangzhou 510515, Guangdong Province, China. baiyang1030@hotmail.com
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Ma F, Chen Y, Li J, Qing HP, Wang JD, Zhang YL, Long BG, Bai Y. Screening test for anti-Helicobacter pylori activity of traditional Chinese herbal medicines. World J Gastroenterol 2010; 16(44): 5629-5634 [PMID: 21105198 DOI: 10.3748/wjg.v16.i44.5629]
World J Gastroenterol. Nov 28, 2010; 16(44): 5629-5634 Published online Nov 28, 2010. doi: 10.3748/wjg.v16.i44.5629
Screening test for anti-Helicobacter pylori activity of traditional Chinese herbal medicines
Feng Ma, Ye Chen, Jing Li, He-Ping Qing, Ji-De Wang, Ya-Li Zhang, Bei-Guo Long, Yang Bai
Feng Ma, Ye Chen, Jing Li, He-Ping Qing, Ji-De Wang, Ya-Li Zhang, Yang Bai, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Bei-Guo Long, Department of Microbiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Author contributions: Ma F and Chen Y performed the majority of experiments, wrote and edited the manuscript; Li J and Qing HP had supportive contributions; Long BG and Wang JD provided the vital reagents and analytical tools; Bai Y and Zhang YL provided the financial support for this work; Bai Y designed the study and edited the manuscript.
Supported by The Cooperation Project in Industry, Education and Research of Guangdong Province and Ministry of Education of China, No. 2009B090300280
Correspondence to: Dr. Yang Bai, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Tonghe Road 1838, Guangzhou 510515, Guangdong Province, China. baiyang1030@hotmail.com
Telephone: +86-20-61641535 Fax: +86-20-87280770
Received: June 1, 2010 Revised: August 3, 2010 Accepted: August 10, 2010 Published online: November 28, 2010
Abstract
AIM: To evaluate the anti-Helicobacter pylori (H. pylori) activity of 50 traditional Chinese herbal medicines in order to provide the primary evidence for their use in clinical practice.
METHODS: A susceptibility test of water extract from 50 selected traditional Chinese herbal medicines for in vitro H. pylori Sydney strain 1 was performed with broth dilution method. Anti-H. pylori activity of the selected Chinese herbal medicines was evaluated according to their minimum inhibitory concentration (MIC).
RESULTS: The water extract from Rhizoma Coptidis, Radix Scutellariae and Radix isatidis could significantly inhibit the H. pylori activity with their MIC less than 7.8 mg/mL, suggesting that traditional Chinese herbal medicines have anti-inflammatory and antibacterial effects and can thus be used in treatment of H. pylori infection.
CONCLUSION: Rhizoma Coptidis, Radix Scutellariae and Radix isatidis are the potential sources for the synthesis of new drugs against H. pylori.
