Sung CM, Hsu CM, Hsu JT, Yeh TS, Lin CJ, Chen TC, Su MY, Chiu CT. Predictive factors for lymph node metastasis in early gastric cancer. World J Gastroenterol 2010; 16(41): 5252-5256 [PMID: 21049560 DOI: 10.3748/wjg.v16.i41.5252]
Corresponding Author of This Article
Cheng-Tang Chiu, MD, Chief, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, 5 Fushing Street, Kweishan Shiang, Taoyuan 333, Taiwan, China. ctchiu@adm.cgmh.org.tw
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Chang-Mu Sung, Chen-Ming Hsu, Chun-Jung Lin, Ming-Yao Su, Cheng-Tang Chiu, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan, China
Jun-Te Hsu, Ta-Sen Yeh, Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan, China
Tse-Ching Chen, Department of Pathology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan, China
Author contributions: Chiu CT designed the research; Sung CM wrote the manuscript; Hsu JT, Hsu CM, Yeh TS, Lin CJ, Chen TC and Su MY provided the cases and suggestions; all authors read and approved the final manuscript.
Correspondence to: Cheng-Tang Chiu, MD, Chief, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, 5 Fushing Street, Kweishan Shiang, Taoyuan 333, Taiwan, China. ctchiu@adm.cgmh.org.tw
Telephone: +886-3-3281200 Fax: +886-3-3285818
Received: May 9, 2010 Revised: June 30, 2010 Accepted: July 7, 2010 Published online: November 7, 2010
Abstract
AIM: To analyze the predictive factors for lymph node metastasis (LNM) in early gastric cancer (EGC).
METHODS: Data from patients surgically treated for gastric cancers between January 1994 and December 2007 were retrospectively collected. Clinicopathological factors were analyzed to identify predictive factors for LNM.
RESULTS: Of the 2936 patients who underwent gastrectomy and lymph node dissection, 556 were diagnosed with EGC and included in this study. Among these, 4.1% of patients had mucosal tumors (T1a) with LNM while 24.3% of patients had submucosal tumors with LNM. Univariate analysis found that female gender, tumors ≥ 2 cm, tumor invasion to the submucosa, vascular and lymphatic involvement were significantly associated with a higher rate of LNM. On multivariate analysis, tumor size, lymphatic involvement, and tumor with submucosal invasion were associated with LNM.
CONCLUSION: Tumor with submucosal invasion, size ≥ 2 cm, and presence of lymphatic involvement are predictive factors for LNM in EGC.
Sung CM, Hsu CM, Hsu JT, Yeh TS, Lin CJ, Chen TC, Su MY, Chiu CT. Predictive factors for lymph node metastasis in early gastric cancer. World J Gastroenterol 2010; 16(41): 5252-5256 [PMID: 21049560 DOI: 10.3748/wjg.v16.i41.5252]
