Danese S, Fiorino G, Angelucci E, Vetrano S, Pagano N, Rando G, Spinelli A, Malesci A, Repici A. Narrow-band imaging endoscopy to assess mucosal angiogenesis in inflammatory bowel disease: A pilot study. World J Gastroenterol 2010; 16(19): 2396-2400 [PMID: 20480525 DOI: 10.3748/wjg.v16.i19.2396]
Corresponding Author of This Article
Silvio Danese, MD, PhD, Division of Gastroenterology, IRCCS Istituto Clinico Humanitas, Viale Manzoni, Rozzano, Milan 20089, Italy. sdanese@hotmail.com
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Danese S, Fiorino G, Angelucci E, Vetrano S, Pagano N, Rando G, Spinelli A, Malesci A, Repici A. Narrow-band imaging endoscopy to assess mucosal angiogenesis in inflammatory bowel disease: A pilot study. World J Gastroenterol 2010; 16(19): 2396-2400 [PMID: 20480525 DOI: 10.3748/wjg.v16.i19.2396]
Antonino Spinelli, Department of Surgery, IRCCS Istituto Clinico Humanitas, Rozzano, Milan 20089, Italy
Alberto Malesci, Department of Translational Medicine, University of Milan, Milan 20100, Italy
Author contributions: Danese S and Repici A designed the study; Danese S, Repici A and Angelucci E analyzed the data and wrote the manuscript; Fiorino G, Vetrano S, Pagano N, Rando G and Spinelli A acquired, analyzed and interpreted the data; Malesci A critically revised the manuscript.
Correspondence to: Silvio Danese, MD, PhD, Division of Gastroenterology, IRCCS Istituto Clinico Humanitas, Viale Manzoni, Rozzano, Milan 20089, Italy. sdanese@hotmail.com
Telephone: +39-2-82244771 Fax: +39-2-82245101
Received: September 17, 2009 Revised: November 5, 2009 Accepted: November 12, 2009 Published online: May 21, 2010
Abstract
AIM: To investigate whether narrow band imaging (NBI) is a useful tool for the in vivo detection of angiogenesis in inflammatory bowel disease (IBD) patients.
METHODS: Conventional and NBI colonoscopy was performed in 14 patients with colonic inflammation (8 ulcerative colitis and 6 Crohn’s disease). Biopsy samples were taken and CD31 expression was assayed immunohistochemically; microvascular density was assessed by vessel count.
RESULTS: In areas that were endoscopically normal but positive on NBI, there was a significant (P < 0.05) increase in angiogenesis (12 ± 1 vessels/field vs 18 ± 2 vessels/field) compared with areas negative on NBI. In addition, in areas that were inflamed on white light endoscopy and positive on NBI, there was a significant (P < 0.01) increase in vessel density (24 ± 7 vessels/field) compared with NBI-negative areas.
CONCLUSION: NBI may allow in vivo imaging of intestinal angiogenesis in IBD patients.
