Hu Y, Lu X, Luo G. Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apcmin mice. World J Gastroenterol 2010; 16(12): 1482-1486 [PMID: 20333788 DOI: 10.3748/wjg.v16.i12.1482]
Corresponding Author of This Article
Guangbin Luo, Assistant Professor, Department of Genetics, Case Comprehensive Cancer Center and University Hospitals of Cleveland, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States. guangbin.luo@case.edu
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World J Gastroenterol. Mar 28, 2010; 16(12): 1482-1486 Published online Mar 28, 2010. doi: 10.3748/wjg.v16.i12.1482
Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apcmin mice
Yiduo Hu, Xincheng Lu, Guangbin Luo
Yiduo Hu, Xincheng Lu, Guangbin Luo, Department of Genetics, Case Comprehensive Cancer Center and University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, United States
Yiduo Hu, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, United States
Author contributions: Hu Y and Luo G designed the research; Hu Y, Lu X and Luo G performed the research; Hu Y and Luo G analyzed the data and wrote the paper.
Supported by Grants RO1 CA88939, P20 CA103736 from the US National Institutes of Health and Searle Scholar Award 01-E-109 from the Searle Scholar Program
Correspondence to: Guangbin Luo, Assistant Professor, Department of Genetics, Case Comprehensive Cancer Center and University Hospitals of Cleveland, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States. guangbin.luo@case.edu
Telephone: +1-216-3684883 Fax: +1-216-3683432
Received: September 30, 2009 Revised: December 19, 2009 Accepted: December 26, 2009 Published online: March 28, 2010
Abstract
AIM: To investigate whether Recql5, a DNA helicase that plays an important role in the maintenance of genome integrity, is a tumor suppressor in the gastrointestinal tract in mice.
METHODS: We generated cohorts of both Recql5-proficient and Recql5-deficient Apcmin/+ mice and compared the tumor susceptibility in their gastrointestinal tracts.
RESULTS: Recql5 deficiency in Apcmin/+ mice resulted in a significant increase in the tumor incidence in both the colon (P = 0.0162) and the small intestine (P < 0.01). These findings have provided the first genetic evidence for a tumor suppression role of Recql5 in the gastrointestinal tract of mice. Importantly, since mouse Recql5 and human RECQL5 are highly conserved, these findings also suggest that RECQL5 may be a tumor suppressor for human colon cancer.
CONCLUSION: Recql5 has a tumor suppression role in the mouse gastrointestinal tract.
