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World J Gastroenterol. Mar 21, 2010; 16(11): 1414-1417
Published online Mar 21, 2010. doi: 10.3748/wjg.v16.i11.1414
Published online Mar 21, 2010. doi: 10.3748/wjg.v16.i11.1414
Interferon-α induced severe thrombocytopenia: A case report and review of the literature
Li Li, Da-Kang Han, Jun Lu, Tumor Biotherapy Ward of Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Author contributions: Lu J drafted and approved the manuscript; Li L and Han DK participated in the design and coordination of the study and performed the literatures analysis; all authors read and approved the final manuscript.
Supported by National High Technology Research and Development Program of China, No. 2007AA02Z151 to Lu J
Correspondence to: Dr. Jun Lu, MD, PhD, Tumor Biotherapy Ward of Beijing Youan Hospital, Capital Medical University, Beijing 100069, China. lujun98@gmail.com
Telephone: +86-10-63291028 Fax: +86-10-63291028
Received: October 18, 2009
Revised: January 5, 2010
Accepted: January 12, 2010
Published online: March 21, 2010
Revised: January 5, 2010
Accepted: January 12, 2010
Published online: March 21, 2010
Abstract
We report a case of severe thrombocytopenia following pegylated interferon-α 2a (Peg-IFN-α 2a) treatment of hepatitis C virus infection and summarize the clinical characteristics of 16 cases of IFN-α induced severe thrombocytopenia and its immune-mediated mechanism. Discontinuation of IFN-α and early administration of immunosuppressants are the effective therapy for IFN-α induced severe thrombocytopenia.
Keywords: Interferon-α; Severe thrombocytopenia; Chronic hepatitis C