Case Report
Copyright ©2009 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Feb 28, 2009; 15(8): 1014-1017
Published online Feb 28, 2009. doi: 10.3748/wjg.15.1014
Nodular liver lesions involving multiple myeloma: A case report and literature review
Xiao-Ning Wu, Xin-Yan Zhao, Ji-Dong Jia
Xiao-Ning Wu, Xin-Yan Zhao, Ji-Dong Jia, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Author contributions: Wu XN provided the data of patients, organized and wrote the manuscript; Zhao XY provided the figures and wrote the manuscript; Jia JD supervised and approved the final manuscript.
Correspondence to: Ji-Dong Jia, MD, PhD, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xuanwu District, Beijing 100050, China. jiamd@263.net
Telephone: +86-10-63139816
Fax: +86-10-83165944
Received: October 8, 2008
Revised: February 1, 2009
Accepted: February 8, 2009
Published online: February 28, 2009
Abstract

We report a case of a 62-year old woman admitted to our hospital for multiple nodular metastatic liver lesions found by ultrasonography in a regular medical examination. Routine laboratory tests were normal. PET-CT showed multiple bone lesions and nodular liver lesions. Liver biopsy revealed nodular infiltration of multiple myeloma with positive staining of kappa light chain. Further investigation of bone marrow aspiration, immunofixation and immunoelectrophoresis of serum protein, urine test for Bence-Jones protein, β2-microglobulin in serum and urine confirmed the diagnosis. The patient also coinfected with hepatitis C virus (HCV). With six cycles of chemotherapy with VAD schedule, she achieved complete remission. In this report, a literature review of liver lesions involving multiple myeloma is also provided.

Keywords: Nodular lesions; Liver; Multiple myeloma; IgA kappa light chain; Hepatitis C virus