Leu JD, Lin IF, Sun YF, Chen SM, Liu CC, Lee YJ. Association between MDM2-SNP309 and hepatocellular carcinoma in Taiwanese population. World J Gastroenterol 2009; 15(44): 5592-5597 [PMID: 19938200 DOI: 10.3748/wjg.15.5592]
Corresponding Author of This Article
Dr. Yi-Jang Lee, Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, No. 155, Sec. 2, Linong St. Beitou District, 112 Taipei, Taiwan, China. yjlee2@ym.edu.tw
Article-Type of This Article
Brief Article
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jyh-Der Leu, Division of Radiation Oncology, Taipei City Hospital Ren Ai Branch, 10629 Taipei, Taiwan, China
I-Feng Lin, Department of Public Health, National Yang-Ming University, 112 Taipei, Taiwan, China
Ying-Fang Sun, Yi-Jang Lee, Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, 112 Taipei, Taiwan, China
Su-Mei Chen, Division of Nuclear Medicine, Taipei City Hospital Ren Ai Branch, 10629 Taipei, Taiwan, China
Chih-Chao Liu, Institute of Environmental and Occupational Healthy Sciences, National Yang-Ming University, 112 Taipei, Taiwan, China
Author contributions: Leu JD was responsible for case and control number design and evaluation; Lin IF and Liu CC performed the statistical analysis and provided interpretation of the results; Sun YF was responsible for DNA extraction and MDM2 SNP309 genotyping; Chen SM was responsible for collection of blood samples, signed consent forms and filled questionnaires; Lee YJ designed the study, carried out the genotyping, investigated the progression of this study and prepared the manuscript; all co-authors read and approved this final manuscript.
Supported by The Department of Health in Taipei City Government, Grant No. 95003-62-129 and a grant from Ministry of Education, aim for the Top University Plan; National Science Council Grant (NSC 96-2321-B-010-006-MY3)
Correspondence to: Dr. Yi-Jang Lee, Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, No. 155, Sec. 2, Linong St. Beitou District, 112 Taipei, Taiwan, China. yjlee2@ym.edu.tw
Telephone: +886-2-28267189 Fax: +886-2-28201095
Received: August 13, 2009 Revised: August 13, 2009 Accepted: October 1, 2009 Published online: November 28, 2009
Abstract
AIM: To investigate the risk association and compare the onset age of hepatocellular carcinoma (HCC) patients in Taiwan with different genotypes of MDM2-SNP309.
METHODS: We analyzed MDM2-SNP309 genotypes from 58 patients with HCC and 138 cancer-free healthy controls consecutively. Genotyping of MDM2-SNP309 was conducted by restriction fragment length polymorphism assay.
RESULTS: The proportion of homozygous MDM2-SNP309 genotype (G/G) in cases and cancer-free healthy controls was similar (17.2% vs 16.7%). Multivariate analysis showed that the risk of G/G genotype of MDM2-SNP309 vs wild-type T/T genotype in patients with HCC was not significant (OR = 1.265, 95% CI = 0.074-21.77) after adjustment for sex, hepatitis B or C virus infection, age, and cardiovascular disease/diabetes. Nevertheless, there was a trend that GG genotype of MDM2-SNP309 might increase the risk in HCC patients infected with hepatitis virus (OR = 2.568, 95% CI = 0.054-121.69). Besides, the homozygous MDM2-SNP309 genotype did not exhibit a significantly earlier age of onset for HCC.
CONCLUSION: Current data suggest that the association between MDM2-SNP309 GG genotype and HCC is not significant, while the risk may be enhanced in patients infected by hepatitis virus in Taiwan.
Leu JD, Lin IF, Sun YF, Chen SM, Liu CC, Lee YJ. Association between MDM2-SNP309 and hepatocellular carcinoma in Taiwanese population. World J Gastroenterol 2009; 15(44): 5592-5597 [PMID: 19938200 DOI: 10.3748/wjg.15.5592]
