World J Gastroenterol. Oct 28, 2009; 15(40): 5106-5108 Published online Oct 28, 2009. doi: 10.3748/wjg.15.5106
Gastric choriocarcinoma admixed with an α-fetoprotein-producing adenocarcinoma and separated adenocarcinoma
Bang Wool Eom, So-Youn Jung, Hongman Yoon, Myeong-Cherl Kook, Keun Won Ryu, Jun Ho Lee, Young-Woo Kim
Bang Wool Eom, So-Youn Jung, Hongman Yoon, Myeong-Cherl Kook, Keun Won Ryu, Jun Ho Lee, Young-Woo Kim, Center for Gastric Cancer, National Cancer Center, 111 Jeongbalsanro, Ilsandong-Gu, Goyang-Si, Gyeonggi-Do 410-769, South Korea
Author contributions: Kim YW designed the research; Eom BW, Jung SY, Kook MC performed the research; Kim YW, Ryu KW, Lee JH, Yoon H contributed new reagents/analytic tools; Eom BW, Jung SY analyzed the data; and Eom BW wrote the paper.
Correspondence to: Young-Woo Kim, MD, Center for Gastric Cancer, National Cancer Center, 111 Jeongbalsanro, Ilsandong-Gu, Goyang-Si, Gyeonggi-Do 410-769, South Korea. gskim@ncc.re.kr
Telephone: +82-31-9201635 Fax: +82-31-9200696
Received: May 27, 2009 Revised: September 10, 2009 Accepted: September 17, 2009 Published online: October 28, 2009
Abstract
We report a case of gastric choriocarcinoma admixed with an α-fetoprotein (AFP)-producing adenocarcinoma. A 70-year-old man was hospitalized for gastric cancer that was detected during screening by esophagogastroduodenoscopy (EGD). Initial laboratory data showed the increased serum level of AFP and EGD revealed a 5-cm ulcerofungating mass in the greater curvature of the gastric antrum. The patient underwent radical subtotal gastrectomy with D2 lymph node dissection and Billroth II gastrojejunostomy. Histopathological evaluation confirmed double primary gastric cancer: gastric choriocarcinoma admixed with an AFP-producing adenocarcinoma and separated adenocarcinoma. At 2 wk postoperatively, his human chorionic gonadotropin and AFP levels had reduced and six cycles of adjuvant chemotherapy were initiated. No recurrence or distant metastasis was observed at 4 years postoperatively.
