Brief Articles
Copyright ©2009 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Aug 28, 2009; 15(32): 4055-4061
Published online Aug 28, 2009. doi: 10.3748/wjg.15.4055
Significance and relationship between Yes-associated protein and survivin expression in gastric carcinoma and precancerous lesions
Chun-Li Da, Yan Xin, Jing Zhao, Xiang-Dong Luo
Chun-Li Da, Yan Xin, Jing Zhao, Xiang-Dong Luo, The Fourth Laboratory of Cancer Institute, Department of Tumor Pathology of General Surgery Institute, the First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Da CL performed the whole study, statistical analysis and wrote the manuscript; Xin Y designed the study, provided financial support, vital experimental equipment for this work and was involved in revising the manuscript; Zhao J and Luo XD participated in the experiment.
Correspondence to: Yan Xin, Professor, The Fourth Laboratory of Cancer Institute, Department of Tumor Pathology of General Surgery Institute, the First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China. yxin@mail.cmu.edu.cn
Telephone: +86-24-83282351
Fax: +86-24-83282375
Received: June 24, 2009
Revised: July 31, 2009
Accepted: August 7, 2009
Published online: August 28, 2009
Abstract

AIM: To analyze the differences and relevance of Yes-associated protein (YAP) and survivin, and to explore the correlation and significance of their expression in gastric carcinoma and precancerous lesions.

METHODS: The PV9000 immunohistochemical method was used to detect the expression of YAP and survivin in 98 cases of normal gastric mucosa, 58 intestinal metaplasia (IM), 32 dysplasia and 98 gastric carcinoma.

RESULTS: The positive rates of YAP in dysplasia (37.5%) and gastric carcinoma (48.0%) were significantly higher than that in normal gastric mucosa (13.3%), P < 0.01. The positive rates of survivin in IM (53.4%), dysplasia (59.4%) and gastric carcinoma (65.3%) were significantly higher than in normal gastric mucosa (11.2%), P < 0.01. Survivin expression gradually increased from 41.7% in well differentiated adenocarcinoma through 58.3% in moderately differentiated adenocarcinoma to 75.6% in poorly differentiated adenocarcinoma, with significant Rank correlation, rk = 0.279, P < 0.01. The positive rate of survivin in gastric carcinoma of diffused type (74.6%) was significantly higher than that in intestinal type (51.3%), P < 0.05. In gastric carcinoma with lymph node metastasis (76.9%), the positive rate of survivin was significantly higher than that in the group without lymph node metastasis (41.2%), P < 0.01. In 98 cases of gastric carcinoma, the expression of YAP and of survivin were positively correlated, rk = 0.246, P < 0.01.

CONCLUSION: YAP may play an important role as a carcinogenic factor and may induce survivin expression. Detecting both markers together may help in early diagnosis of gastric carcinoma.

Keywords: Apoptosis; Cell proliferation; Gastric cancer; Immunohistochemistry; Neoplastic processes; Survivin protein; Yes-associated protein