Hao JY, Wu DF, Wang YZ, Gao YX, Lang HP, Zhou WZ. Prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography pancreatitis: A randomized placebo-controlled trial. World J Gastroenterol 2009; 15(3): 366-368 [PMID: 19140238 DOI: 10.3748/wjg.15.366]
Corresponding Author of This Article
Jian-Yu Hao, Professor, MD, Department of Digestion, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China. ylxyyn@hotmail.com
Article-Type of This Article
Brief Articles
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jian-Yu Hao, Dong-Fang Wu, Yue-Zeng Wang, Ying-Xin Gao, Hai-Po Lang, Wei-Zhen Zhou, Department of Digestion, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China
Author contributions: Hao JY, Wu DF and Wang YZ treated the patients, analyzed the data and wrote the manuscript; Gao YX, Lang HP and Zhou WZ collected the data.
Correspondence to: Jian-Yu Hao, Professor, MD, Department of Digestion, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China. ylxyyn@hotmail.com
Telephone: +86-10-85231502
Fax: +86-10-85232985
Received: September 12, 2008 Revised: December 12, 2008 Accepted: December 19, 2008 Published online: January 21, 2009
Abstract
AIM: To examine the prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and hyperamylasemia.
METHODS: Patients scheduled for ERCP were randomly divided into study group and placebo group. Patients in study group and placebo group were treated with 5 mg glyceryl trinitrate and 100 mg vitamin C, respectively, 5 min before endoscopic maneuvers.
RESULTS: A total of 74 patients were enrolled in the final analysis. Post-ERCP pancreatitis occurred in 3 patients (7.9%) of the study group and 9 patients (25%) in the placebo group (P = 0.012). Hyperamylasemia occurred in 8 patients of the study group (21.1%) and 13 patients (36.1%) of the placebo group (P = 0.037).
CONCLUSION: Glyceryl trinitrate before ERCP can effectively prevent post-ERCP and hyperamylasemia.
