Brief Articles
Copyright ©2009 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Jan 21, 2009; 15(3): 366-368
Published online Jan 21, 2009. doi: 10.3748/wjg.15.366
Prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography pancreatitis: A randomized placebo-controlled trial
Jian-Yu Hao, Dong-Fang Wu, Yue-Zeng Wang, Ying-Xin Gao, Hai-Po Lang, Wei-Zhen Zhou
Jian-Yu Hao, Dong-Fang Wu, Yue-Zeng Wang, Ying-Xin Gao, Hai-Po Lang, Wei-Zhen Zhou, Department of Digestion, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China
Author contributions: Hao JY, Wu DF and Wang YZ treated the patients, analyzed the data and wrote the manuscript; Gao YX, Lang HP and Zhou WZ collected the data.
Correspondence to: Jian-Yu Hao, Professor, MD, Department of Digestion, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China. ylxyyn@hotmail.com
Telephone: +86-10-85231502
Fax: +86-10-85232985
Received: September 12, 2008
Revised: December 12, 2008
Accepted: December 19, 2008
Published online: January 21, 2009
Abstract

AIM: To examine the prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and hyperamylasemia.

METHODS: Patients scheduled for ERCP were randomly divided into study group and placebo group. Patients in study group and placebo group were treated with 5 mg glyceryl trinitrate and 100 mg vitamin C, respectively, 5 min before endoscopic maneuvers.

RESULTS: A total of 74 patients were enrolled in the final analysis. Post-ERCP pancreatitis occurred in 3 patients (7.9%) of the study group and 9 patients (25%) in the placebo group (P = 0.012). Hyperamylasemia occurred in 8 patients of the study group (21.1%) and 13 patients (36.1%) of the placebo group (P = 0.037).

CONCLUSION: Glyceryl trinitrate before ERCP can effectively prevent post-ERCP and hyperamylasemia.

Keywords: Glyceryl trinitrate; Cholangiopancreatography; Endoscopic retrograde; Pancreatitis