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World J Gastroenterol. Mar 28, 2009; 15(12): 1512-1517
Published online Mar 28, 2009. doi: 10.3748/wjg.15.1512
Lung tissue flap repairs esophagus defection with an inner chitosan tube stent
Gang Chen, Wen-Jun Shi
Gang Chen, Wen-Jun Shi, Department of Thoracic Surgery, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Chen G and Shi WJ contributed equally to this work; Shi WJ designed the research; Chen G and Shi WJ performed the research; Chen G contributed to the new chitosan tube stent; Chen G and Shi WJ analyzed the picture and wrote the paper.
Correspondence to: Dr. Wen-Jun Shi, Department of Thoracic Surgery, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China. xy7224@sina.com
Telephone: +86-24-83955064
Fax: +86-24-83955064
Received: July 25, 2008
Revised: December 16, 2008
Accepted: December 23, 2008
Published online: March 28, 2009
Abstract

AIM: To repair the partial esophagus defect with a chitosan stent, a new esophageal prosthesis made of pulmonary tissue with vascular pedicle.

METHODS: Fifteen Japanese big ear white rabbits were divided into experimental group (n = 10) and control group (n = 5). Esophagus defect in rabbits of experimental group was repaired using lung tissue flap with a chitosan tube stent, gross and histological appearance was observed at week 2, 4 and 8 after operation, and barium sulphate X-ray screen was performed at week 10 after operation. Esophagus defect of rabbits in control group was repaired using lung tissue flap with no chitosan tube stent, gross and histological appearance was observed at week 2, 4 and 8 after operation, and barium sulphate X-ray screen was performed at week 10 after operation.

RESULTS: In the experimental group, 6 rabbits survived for over two weeks, the lung tissue flap healed esophageal defection, and squamous metaplasia occurred on the surface of lung tissue flap. At week 10 after operation, barium sulphate examination found that barium was fluent through the esophagus with no stricture or back stream, the creeping was good. In the control group, 4 rabbits survived for two weeks, the lung tissue flap healed esophageal defection with fibrous tissue hyperplasia, barium sulphate examination found that barium was fluent through the esophagus with a slight stricture or back stream, and the creeping was not good at week 10 after operation.

CONCLUSION: Esophagus defect can be repaired using lung tissue flap with an inner chitosan tube stent.

Keywords: Lung; Tissue flap; Chitosan; Stent; Esophagus reconstruction