Rapid Communication
Copyright ©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Feb 7, 2008; 14(5): 771-775
Published online Feb 7, 2008. doi: 10.3748/wjg.14.771
Relationship and significance between anti-β2-glycoproteinI antibodies and platelet activation state in patients with ulcerative colitis
Yan-Hang Gao, Pu-Jun Gao, Chun-Guang Wang, Xiao-Cong Wang, Yun-Feng Piao
Yan-Hang Gao, Pu-Jun Gao, Xiao-Cong Wang, Yun-Feng Piao, Department of Gastroentology, The First Affiliated Hospital, Jilin University, Changchun 130021, Jilin Province, China
Chun-Guang Wang, Department of Chest Surgery, The Second Affiliated Hospital, Jilin University, Changchun 130041, Jilin Province, China
Correspondence to: Dr. Pu-Jun Gao, Department of Gastro-entology, The First Affiliated Hospital, Jilin University, 71 Xinmin Street, Changchun 130021, Jilin Province, China. pujun-gao@163.com
Telephone: +86-431-85612162
Received: September 26, 2007
Revised: December 5, 2007
Published online: February 7, 2008
Abstract

AIM: To study the relationship between anti-β2-glycoprotein I (aβ2GPI) antibodies and platelet activation state in patients with ulcerative colitis (UC) and its significance.

METHODS: Peripheral blood samples were collected from 56 UC patients (34 males and 22 females, aged 43.5 years, range 21-66 years), including 36 at active stage and 20 at remission stage, and 25 sex-and age-matched controls. The level of aβ2GPI was measured by ELISA. The platelet activation markers, platelet activation complex-I (PAC-I) and P-selectin (CD62P) were detected by flow cytometry.

RESULTS: The A value for IgG aβ2GPI in the active UC group was 0.61 ± 0.13, significantly higher than that in the remittent UC and control groups (0.50 ± 0.13 and 0.22 ± 0.14, P < 0.01). There was a significant difference between the two groups (P < 0.01). The A value for IgM aβ2GPI in the active and remittent UC groups was 0.43 ± 0.13 and 0.38 ± 0.12, significantly higher than that in the control group (0.20 ± 0.12, P < 0.01). However, there was no significant difference between the two groups (P > 0.05). The PAC-I positive rate for the active and remittent UC groups was 30.6% ± 7.6% and 19.6% ± 7.8% respectively, significantly higher than that for the control group (6.3% ± 1.7%, P < 0.01). There was a significant difference between the two groups (P < 0.01). The CD62P positive rate for the active and remittent UC groups was 45.0% ± 8.8% and 31.9% ± 7.8% respectively, significantly higher than that for the control group (9.2% ± 2.7%, P < 0.01). There was a significant difference between the two groups (P < 0.01). In the active UC group, the more severe the state of illness was, the higher the A value for IgG aβ2GPI was, and the positive rate for PAC-I and CD62P was positively correlated with the state of illness (Faβ2GPI = 3.679, P < 0.05; FPAC-I (%) = 5.346, P < 0.01; and FCD62P (%) = 5. 418, P < 0.01). Meanwhile, in the same state of illness, the A value for IgG aβ2GPI was positively correlated to the positive rates for PAC-I and CD62P.

CONCLUSION: aβ2GPI level, platelet activation state and their relationship of them are closely correlated with the pathogenesis and development of UC.

Keywords: β2-glycoproteinI; Anti-β2-glycoproteinI antibodies; Ulcerative colitis; Platelet activation; Hypercoagulation