XRCC1 genetic polymorphism Arg399Gln and gastric cancer risk: A meta-analysis

doi:10.3748/wjg.14.6733

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Nov 21, 2008; 14(43): 6733-6737
Published online Nov 21, 2008. doi: 10.3748/wjg.14.6733

XRCC1 genetic polymorphism Arg399Gln and gastric cancer risk: A meta-analysis

Jian Geng, You-Wei Zhang, Gui-Chun Huang, Long-Bang Chen

Jian Geng, You-Wei Zhang, Gui-Chun Huang, Long-Bang Chen, Department of Oncology, Nanjing University School of Medicine, Jinling Hospital, 305 Zhongshan East Road, Nanjing 210002, Jiangsu Province, China

Author contributions: Geng J and Chen LB designed the research; Geng J, Zhang YW and Huang GC performed the research; Geng J wrote the paper.

Correspondence to: Long-Bang Chen, Department of Oncology, Nanjing University School of Medicine, Jinling Hospital, 305 Zhongshan East Road, Nanjing 210002, Jiangsu Province, China. longbangchen@sina.com

Telephone: +86-25-80860123 Fax: +86-25-80860123

Received: June 9, 2008
Revised: August 17, 2008
Accepted: August 24, 2008
Published online: November 21, 2008

Abstract

AIM: To evaluate the association between X-ray cross-complementing gene 1 (XRCC1) genetic polymorphism Arg399Gln and gastric cancer risk by means of meta-analysis.

METHODS: We searched PubMed and NCBI up to June 1, 2008. A total of 16 clinical trials and reports were identified, but only 8 trials qualified under our selection criteria. Statistical analysis was performed with the software program Review Manage, version 4.2.8.

RESULTS: Of the 8 case-control studies selected for this meta-analysis, a total of 1334 gastric cancer cases and 2194 controls were included. For Arg399Gln, the Gln/Gln genotype carriers did not have a decreased cancer risk compared with those individuals with the Arg/Arg genotype (OR = 0.92, 95% CI, 0.71-1.19; P = 0.51). Similarly, no associations were found in the recessive and dominant modeling (Gln/Gln vs Arg/Gln + Arg/Arg: OR = 0.96; 95% CI, 0.77-1.19; P = 0.70 and Gln/Gln + Arg/Gln vs Arg/Arg: OR = 0.90, 95% CI, 0.77-1.05; P = 0.18).

CONCLUSION: No association is found between the XRCC1 polymorphism Arg399Gln and gastric cancer risk.

Keywords: Gastric cancer; Gene polymorphism; X-ray cross-complementing gene 1; Meta-analysis