Case Report
Copyright ©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Oct 14, 2008; 14(38): 5927-5929
Published online Oct 14, 2008. doi: 10.3748/wjg.14.5927
Intraperitoneal dedifferentiated liposarcoma: A case report
Ali Karaman, Mehmet Eşref Kabalar, Önder Özcan, Timur Koca, Doğan Nasır Binici
Ali Karaman, Department of Medical Genetics, State Hospital, Erzurum 25240, Turkey
Mehmet Eşref Kabalar, Department of Pathology, State Hospital, Erzurum 25240, Turkey
Önder Özcan, Department of General Surgery, State Hospital, Erzurum 25240, Turkey
Timur Koca, Department of Radiation Oncology, State Hospital, Erzurum 25240, Turkey
Doğan Nasır Binici, Department of Internal Medicine, State Hospital, Erzurum 25240, Turkey
Author contributions: Karaman A performed the PCR analysis of adipose tumor samples and wrote the article; Kabalar ME analyzed the biopsy material; Binici DN performed the physical examination; Özcan Ö performed the surgical operation; Koca T performed the radiation therapy.
Correspondence to: Ali Karaman, MD, Erzurum State Hospital, (Erzurum Numune Hastanesi), Department of Medical Genetics, Erzurum 25240, Turkey. alikaramandr@hotmail.com
Telephone: +90-442-2321139 Fax: +90-442-2321390
Received: June 30, 2008
Revised: August 27, 2008
Accepted: September 3, 2008
Published online: October 14, 2008
Abstract

Dedifferentiated liposarcoma is a variant of liposarcoma with a more aggressive course. Mutations of the p53 gene have been found in different types of soft tissue sarcoma. It is generally accepted that p53 mutations in human malignant tumors are often related to a poor prognosis. In our case, analysis of p53 gene mutation in tumor samples was performed. p53 gene mutation was observed in dedifferentiated tumor tissue samples but not in well-differentiated tumor tissue samples. It has been reported that p53 gene mutation occurs most commonly in the retroperitoneum and rarely in other anatomic locations. Herein we report a case of dedifferentiated liposarcoma located at intraperitoneum.

Keywords: Dedifferentiated liposarcoma; p53 gene; Mutation; Intraperitoneum