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World J Gastroenterol. Aug 28, 2008; 14(32): 5073-5077
Published online Aug 28, 2008. doi: 10.3748/wjg.14.5073
Treatment of upper gastrointestinal fistula and leakage with personal stage nutrition support
Qun Wang, Zhi-Su Liu, Qun Qian, Quan Sun, Ding-Yu Pan, Yue-Ming He
Qun Wang, Zhi-Su Liu, Qun Qian, Quan Sun, Ding-Yu Pan, Department of General Surgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, China
Yue-Ming He, Department of Digestive Disease Research Center of Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, China
Author contributions: Wang Q and Liu ZS contributed equally to this work; Wang Q, Liu ZS and Pan DY designed the research; Wang Q, Liu ZS, Pan DY ,Qian Q and Sun Q performed the research; Wang Q, He YM, Liu ZS and Pan DY analyzed the data; and Wang Q wrote the paper.
Correspondence to: Zhi-Su Liu, Professor, Department of General Surgery, Zhongnan Hospital, Wuhan University, No. 169, Donghu Road, Wuhan 430071, Hubei Province, China. swander@126.com
Telephone: +86-27-67813007 Fax: +86-27-87330795
Received: December 23, 2007
Revised: July 14, 2008
Accepted: July 21, 2008
Published online: August 28, 2008
Abstract

AIM: To investigate the feasibility of treatment for upper gastrointestinal fistula and leakage with personal stage nutrition support.

METHODS: Forty-three patients with upper gastrointestinal fistula and leakage were randomly divided into two groups. Patients in group A were treated with personal stage nutrition support and patients in group B were treated with total parental nutrition (TPN) in combination with operation. Nutritional states of the candidates were evaluated by detecting albumin (Alb) and pre-Alb. The balance between nutrition and hepatic function was evaluated by measurement of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (Tbill) before and after operation. At the same time their complications and hospitalized time were surveyed.

RESULTS: Personal stage nutrition support improved upper gastrointestinal fistula and leakage. The nutrition state and hepatic function were better in patients who received personal stage nutrition support than in those who did not receive TPN. There was no significant difference in the complication and hospitalized time in the two groups of patients.

CONCLUSION: Upper gastrointestinal fistula and leakage can be treated with personal stage nutrition support which is more beneficial for the post-operation recovery and more economic than surgical operation.

Keywords: Personal stage nutrition support; Treatment; Upper gastrointestinal fistula and leakage; Total parental nutrition; Enteral nutrition