Copyright
©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Aug 14, 2008; 14(30): 4830-4833
Published online Aug 14, 2008. doi: 10.3748/wjg.14.4830
Published online Aug 14, 2008. doi: 10.3748/wjg.14.4830
Unexpected discovery of 2 cases of hepatocyte nuclear factor 1α-mutated infracentimetric adenomatosis
Hervé Laumonier, Department of Radiology, Hôpital Saint André, CHU Bordeaux, Bordeaux 33075, France
Anne Rullier, Paulette Bioulac-Sage, Department of Pathology, Hôpital Pellegrin, CHU Bordeaux, Bordeaux 33075, France
Anne Rullier, Paulette Bioulac-Sage, Charles Balabaud, INSERM, U889, Bordeaux, France and Université Victor Segalen Bordeaux 2, IFR66, Bordeaux 33075, France
Jean Saric, Department of Surgery, Hôpital Saint André, CHU Bordeaux, Bordeaux 33075, France
Charles Balabaud, Department of Hepatology, Hôpital Saint André, CHU Bordeaux, Bordeaux 33075, France
Author contributions: Laumonier H and Rullier A contributed equally to this work; Laumonier H performed the imaging technique and Rullier A made the pathological diagnosis; Saric J performed the surgery; Bioulac-Sage P and Balabaud C designed the study; Laumonier H and Rullier A wrote the paper.
Correspondence to: Dr. Hervé Laumonier, Service de radiology, Hôpital St André, 1 rue Jean Burguet, Bordeaux 33075, France. herve.laumonier@chu-bordeaux.fr
Telephone: +33-6-63932146 Fax: +33-5-56794764
Received: January 18, 2008
Revised: June 18, 2008
Accepted: June 25, 2008
Published online: August 14, 2008
Revised: June 18, 2008
Accepted: June 25, 2008
Published online: August 14, 2008
Abstract
We present 2 cases of hepatocyte nuclear factor 1α (HNF1α)-mutated adenomatosis, discovered for reasons unrelated to this disease, and identified using immunohistochemical methods. These new tools may further our understanding of the link between adenomas/adenomatosis subtypes and their complications, and their association with other abnormalities.
Keywords: Hepatocellular adenoma; Adenomatosis; Hepatocyte nuclear factor 1; Hepatocyte nuclear factor 1α mutation; β-catenin mutation; Focal nodular hyperplasia