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Copyright ©2008 The WJG Press and Baishidengs. All rights reserved.
World J Gastroenterol. Aug 7, 2008; 14(29): 4684-4689
Published online Aug 7, 2008. doi: 10.3748/wjg.14.4684
Inhibition of hepatitis B virus gene expression and replication by artificial microRNA
Yu-Feng Gao, Li Yu, Wei Wei, Jia-Bin Li, Qing-Li Luo, Ji-Long Shen
Yu-Feng Gao, Li Yu, Wei Wei, Ji-Long Shen, Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, Anhui Province, China
Yu-Feng Gao, Li Yu, Qing-Li Luo, Ji-Long Shen, Anhui Key Laboratory of Zoonoses, Hefei 230032, Anhui Province, China
Yu-Feng Gao, Li Yu, Qing-Li Luo, Ji-Long Shen, The Key Laboratory of Gene Resource Utilization for Severe Diseases, The Ministry of Education of China and Anhui Province, Hefei 230032, Anhui Province, China
Yu-Feng Gao, Jia-Bin Li, Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China
Author contributions: Gao YF, Wei W and Shen JL designed the research; Gao YF, Yu L and Luo QL performed the research and analyzed data; Gao YF, Yu L, Luo QL and Li JB wrote the paper.
Correspondence to: Ji-Long Shen, Professor, Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, Anhui Province, China. shenjilong53@126.com
Telephone: +86-551-5161057
Fax: +86-551-5161057
Received: April 28, 2008
Revised: June 16, 2008
Accepted: June 23, 2008
Published online: August 7, 2008
Abstract

AIM: To investigate the inhibitory effects of hepatitis B virus (HBV) replication and expression by transfecting artificial microRNA (amiRNA) into HepG2.2.15 cells.

METHODS: Three amiRNA-HBV plasmids were constructed and transfected into HepG2.2.15 cells. HBV antigen secretion was detected in the cells with transient and stable transfection by time-resolved fluoroimmunoassays (TRFIA). HBV DNA replication was examined by fluorescence quantitative PCR, and the level of HBV S mRNA was measured by semi-quantitative RT-PCR.

RESULTS: The efficiency of transient transfection of the vectors into 2.2.15 cells was 55%-60%. All the vectors had significant inhibition effects on HBsAg and HBeAg at 72 h and 96 h after transfection (P < 0.01 for all). The secretion of HBsAg and HBeAg into the supernatant was inhibited by 49.8% ± 4.7% and 39.9% ± 6.7%, respectively, at 72 h in amiRNA-HBV-S608 plasmid transfection group. The copy of HBV DNA within culture supernatant was also significantly decreased at 72 h and 96 h after transfection (P < 0.01 for all). In the cells with stable transfection, the secretion of HBsAg and HBeAg into the supernatant was significantly inhibited in all three transfection groups (P < 0.01 for all, vs negative control). The copies of HBV DNA were inhibited by 33.4% ± 3.0%, 60.8% ± 2.3% and 70.1% ± 3.3%, respectively.

CONCLUSION: In HepG2.2.15 cells, HBV replication and expression could be inhibited by artificial microRNA targeting the HBV S coding region. Vector-based artificial microRNA could be a promising therapeutic approach for chronic HBV infection.

Keywords: Hepatitis B virus; RNA interference; Artificial microRNA; HepG2.2.15 cell