Yamagishi H, Koike T, Ohara S, Kobayashi S, Ariizumi K, Abe Y, Iijima K, Imatani A, Inomata Y, Kato K, Shibuya D, Aida S, Shimosegawa T. Tongue-like Barrett’s esophagus is associated with gastroesophageal reflux disease. World J Gastroenterol 2008; 14(26): 4196-4203 [PMID: 18636666 DOI: 10.3748/wjg.14.4196]
Corresponding Author of This Article
Hatsushi Yamagishi, MD, Division of Gastroenterology, Tohoku University graduate school of medicine, 1-1 Seiryou-Machi, Aobaku, Sendai 980-8574, Japan. hatsushi@f2.dion.ne.jp
Article-Type of This Article
Rapid Communication
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Hatsushi Yamagishi, Tomoyuki Koike, Shuichi Ohara, Shigeyuki Kobayashi, Ken Ariizumi, Yasuhiko Abe, Katsunori Iijima, Akira Imatani, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan
Yoshifumi Inomata, Katsuaki Kato, Daisuke Shibuya, Miyagi Cancer Society, Sendai, 980-0011, Japan
Shigemitsu Aida, Department of Gastroenterlogy, Sendai City Hospital, Sendai 984-8501, Japan
Author contributions: Yamagishi H, Koike T, Ohara S and Abe Y designed research; Yamagishi H, Koike T, Ohara S, Kobayashi S, Ariizumi K, Abe Y, Iijima K, Imatani A, Inomata Y, Kato K, Shibuya D, Aida S and Shimosegawa T performed research; Yamagishi H, Koike T, Ohara S and Abe Y analyzed data; Yamagishi H, Koike T and Ohara S wrote the paper.
Correspondence to: Hatsushi Yamagishi, MD, Division of Gastroenterology, Tohoku University graduate school of medicine, 1-1 Seiryou-Machi, Aobaku, Sendai 980-8574, Japan. hatsushi@f2.dion.ne.jp
Telephone: +81-22-7177171
Fax: +81-22-7177177
Received: March 10, 2008 Revised: May 19, 2008 Accepted: May 26, 2008 Published online: July 14, 2008
Abstract
AIM: To test this hypothesis of barrett esophagus (BE) classified into two types and to further determine if there was any correlation between the shape of endoscopically suspected esophageal metaplasia (ESEM), prevalence of reflux esophagitis (RE) and heartburn.
METHODS: A total of 6504 Japanese who underwent endoscopy for their annual stomach check-up were enrolled in this study. BE was detected without histological confirmation that is ESEM. We originally classified cases of ESEM into 3 types based on its shape: Tongue-like (T type), Dome-like (D type) and Wave-like (W type) ESEM. The respective subjects were prospectively asked to complete questionnaires concerning the symptoms of heartburn, dysphagia, and abdominal pain for a one-month period.
RESULTS: ESEM was observed in 10.3% of 6504 subjects (ESEM < 1 cm, 9.4%; 1 cm ≤ ESEM < 3 cm, 1.7%; ESEM ≥ 3 cm, 0.5%). The frequency of ESEM was significantly higher in males compared with female subjects. Statistical analysis showed that the prevalence of heartburn and RE were significantly higher in the T type ESEM than in the W type ESEM (P < 0.05).
CONCLUSION: The T type ESEM was strongly asso-ciated with reflux symptoms and RE whereas the W type ESEM was not associated with GERD.
