Gencay C, Kilicoglu SS, Kismet K, Kilicoglu B, Erel S, Muratoglu S, Sunay AE, Erdemli E, Akkus MA. Effect of honey on bacterial translocation and intestinal morphology in obstructive jaundice. World J Gastroenterol 2008; 14(21): 3410-3415 [PMID: 18528939 DOI: 10.3748/wjg.14.3410]
Corresponding Author of This Article
Dr. Bulent Kilicoglu, Ankara Training and Research Hospital 4th General Surgery Department, S.B. Ankara Egitim ve Arastirma Hastanesi 4 Cerrahi Klinigi, 06340, Ulucanlar, Ankara 06370, Turkey. kilicoglubulent@yahoo.com
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Basic Research
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World J Gastroenterol. Jun 7, 2008; 14(21): 3410-3415 Published online Jun 7, 2008. doi: 10.3748/wjg.14.3410
Effect of honey on bacterial translocation and intestinal morphology in obstructive jaundice
Cem Gencay, Sibel Serin Kilicoglu, Kemal Kismet, Bulent Kilicoglu, Serap Erel, Sabahattin Muratoglu, Asli Elif Sunay, Esra Erdemli, Mehmet Ali Akkus
Cem Gencay, Kemal Kismet, Bulent Kilicoglu, Serap Erel, Mehmet Ali Akkus, Ankara Training and Research Hospital 4th General Surgery Department, Ankara 06340, Turkey
Sibel Serin Kilicoglu, Ufuk University School of Medicine, Department of Histology and Embryology, Ankara 06800, Turkey
Sabahattin Muratoglu, Ankara Training and Research Hospital Microbiology Department, Ankara 06340, Turkey
Asli Elif Sunay, Food Engineer, Balparmak Pazarlama, 34760, Cekmekoy, Istanbul Turkey
Esra Erdemli, Ankara University School of Medicine, Department of Histology and Embryology, Ankara 06370, Turkey
Author contributions: Gencay C, Kilicoglu B and Kismet K contributed equally to this work, Kilicoglu SS and Erdemli E performed histological examination, Muratoglu S performed microbiological examination, Akkus MA and Erel S analyzed data; Kismet K and Kilicoglu B wrote the paper.
Correspondence to: Dr. Bulent Kilicoglu, Ankara Training and Research Hospital 4th General Surgery Department, S.B. Ankara Egitim ve Arastirma Hastanesi 4 Cerrahi Klinigi, 06340, Ulucanlar, Ankara 06370, Turkey. kilicoglubulent@yahoo.com
Telephone: +90-312-5953449
Fax: +90-312-3633396
Received: March 19, 2008 Revised: May 6, 2008 Accepted: May 13, 2008 Published online: June 7, 2008
Abstract
AIM: To evaluate the effects of honey on bacterial translocation and intestinal villus histopathology in experimental obstructive jaundice.
METHODS: Thirty Wistar-Albino rats were randomly divided into three groups each including 10 animals: group I, sham-operated; group II, ligation and section of the common bile duct (BDL); group III, bile duct ligation followed by oral supplementation of honey (BDL + honey) 10 g/kg per day. Liver, blood, spleen, mesenteric lymph nodes, and ileal samples were taken for microbiological, light and transmission electrone microscopic examination.
RESULTS: Although the number of villi per centimeter and the height of the mucosa were higher in sham group, there was no statistically significant difference between sham and BDL + honey groups (P > 0.05). On the other hand, there was a statistically significant difference between BDL group and other groups (P < 0.05). The electron microscopic changes were also different between these groups. Sham and honey groups had similar incidence of bacterial translocation (P > 0.05). BDL group had significantly higher rates of bacterial translocation as compared with sham and honey groups. Bacterial translocation was predominantly detected in mesenteric lymph nodes.
CONCLUSION: Supplementation of honey in presence of obstructive jaundice ameliorates bacterial translocation and improves ileal morphology.
