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©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Apr 7, 2008; 14(13): 2126-2127
Published online Apr 7, 2008. doi: 10.3748/wjg.14.2126
Published online Apr 7, 2008. doi: 10.3748/wjg.14.2126
Role of ABCC2 common variants in intrahepatic cholestasis of pregnancy
Silvia Sookoian, Carlos J Pirola, Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A. Lanari, University of Buenos Aires-CONICET, Buenos Aires 1427, Argentina
Silvia Sookoian, Gustavo Castaño, Research Council of GCBA, Buenos Aires 1427, Argentina
Author contributions: Sookoian S, Castaño G, and Pirola CJ designed and performed the research; Sookoian S and Pirola CJ wrote the paper; Pirola CJ the analyzed data.
Correspondence to: Silvia Sookoian, MD, PhD, Instituto de Investigaciones Médicas A. Lanari-Conicet, Combatiente de Malvinas 3150, Buenos Aires 1427, Argentina. ssookoian@lanari.fmed.uba.ar
Telephone: +54-11-45148701
Fax: +54-11-45238947
Received: January 9, 2008
Revised: February 19, 2008
Published online: April 7, 2008
Revised: February 19, 2008
Published online: April 7, 2008
Abstract
The pathogenesis of intrahepatic cholestasis of pregnancy (ICP), a disorder that adversely affects maternal wellbeing and fetal outcome, is unclear. However, multiple factors probably interact along with a genetic predisposition. We would like to add some comments on a paper recently published concerning the role of ABCB11 and ABCC2 polymorphisms in both ICP and contraceptive-induced cholestasis, especially in the light of our recently published findings about a positive association between ICP and ABCC2 common variants.
Keywords: Intrahepatic cholestasis of pregnancy; ABCC2; MRP2; Gene variants