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World J Gastroenterol. Jan 7, 2008; 14(1): 81-84
Published online Jan 7, 2008. doi: 10.3748/wjg.14.81
Effects of primary suture and fib sealant on hemostasis and liver regeneration in an experimental liver injury
Arif Hakan Demirel, Ozgur Taylan Basar, Ali Ulvi Ongoren, Erkut Bayram, Mustafa Kisakurek
Arif Hakan Demirel, Ali Ulvi Ongoren, 2nd Department of General Surgery, Ministry of Health Ankara Training and Research Hospital, Ankara 06120, Turkey
Ozgur Taylan Basar, Erkut Bayram, Mustafa Kisakurek, 5th Department of General Surgery, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey
Correspondence to: Arif Hakan Demirel, 2nd Department of General Surgery, Ministry of Health Ankara Training and Research Hospital, 12.cad. 43.sok.No:16/19, Sayistay sit, Demetevler-06200, Ankara, Turkey. arifhakand@gmail.com
Telephone: +90-312-5953423
Fax: +90-312-3633396
Received: July 17, 2007
Revised: September 22, 2007
Published online: January 7, 2008
Abstract

AIM: To investigate the effects of fib sealant on hemostasis and liver regeneration and intra-abdominal adhesions in an experimental liver injury.

METHODS: Thirty-six Wistar rats were randomly divided into primary suture group (n = 15), fib sealant group (n = 15) and control group (n = 6). A wedge resection was performed on the left lobe of the liver. In primary suture group, liver was sutured using polypropylene material, while fib glue was administrated on the liver surface in fib sealant group.

RESULTS: More intra-abdominal adhesions were observed in the primary suture group compared to the fib sealant group on 3rd (2.50 ± 0.5 vs 0.25 ± 0.5, P = 0.015), 10th (2.75 ± 0.5 vs 0.50 ± 0.6, P = 0.06) and 20th (1.75 ± 0.5 vs 0.70 ± 0.5, P = 0.015) postoperative days. Histopathological scores were better in the fib sealant group in comparison with the primary suture group on 3rd (8.75 ± 0.5 vs 6.75 ± 0.5, P = 0.006), 10th (7.50 ± 1.0 vs 5.5 ± 0.6, P = 0.021) and 20th (6.40 ± 1.7 vs 3.20 ± 1.6, P = 0.025) postoperative days.

CONCLUSION: Out data suggest that fib sealant is preferred over primary suture in appropriate cases including liver trauma since it causes less intra-abdominal adhesions while allowing shorter hemostasis time as assessed in experimental liver trauma.

Keywords: Liver; Trauma; Fib sealant; Hemostasis; Regeneration