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World J Gastroenterol. Feb 28, 2007; 13(8): 1243-1246
Published online Feb 28, 2007. doi: 10.3748/wjg.v13.i8.1243
Effects of the myeloperoxidase 463 gene polymorphisms on development of atrophy in H pylori infected or noninfected gastroduodenal disease
Ömer Yilmaz, Hakan Dursun, Nesrin Gürsan, İbrahim Pirim, Arif Yılmaz, Nihat Okcu
Ömer Yilmaz, Hakan Dursun, Arif Yılmaz, Nihat Okcu, Department of Gastroenterology, Faculty of Medicine, University of Atatürk, Erzurum 25070, Turkey
Nesrin Gürsan, Department of Pathology, Faculty of Medicine, University of Atatürk, Erzurum 25070, Turkey
İbrahim Pirim, Department of Medical Biology and Genetics, Faculty of Medicine, University of Atatürk, Erzurum 25070, Turkey
Author contributions: All authors contributed equally to the work.
Correspondence to: Ömer Yilmaz, MD, Atatürk University, Medical Faculty, Department of Gastroenterology, Erzurum 25070, Turkey. yilmazo@atauni.edu.tr
Telephone: +90-442-2361212 Fax: +90-442-2361301
Received: November 3, 2006
Revised: December 1, 2006
Accepted: December 18, 2006
Published online: February 28, 2007
Abstract

AIM: To investigate the relationship between myelo-peroxidase polymorphisms as a host-related factor and atrophy caused by H pylori.

METHODS: Our study enrolled 77 patients. Biopsy materials obtained during gastrointestinal endoscopies were evaluated for the presence of H pylori. Polymerase chain reaction-restriction fragment length polymorphism assay was used to characterize myeloperoxidase genotypes.

RESULTS: Forty four patients (57.1%) were Hp (+) and 33 (42.9%) were Hp (-). Sixty six (85.7%) had GG genotype, 10 (12.9%) had GA genotype and 1 (1.29%) had AA genotype. The change in atrophy in relation to neutrophil infiltration was significant in Hp (+) patients (P = 0.0001). The change in atrophy in relation to neutrophil infiltration in patients with GG genotype was significant (P = 0.002). However, the change in atrophy in relation to neutrophil infiltration was not significiant in patients with Hp (+) GG genotype (r = 0.066, P = 0.63).

CONCLUSION: Myeloperoxidase genotype is critical for development of atrophy in relation to the severity of inflammation. However, it is interesting to note that, H pylori does not show any additive effect on development of atrophy.

Keywords: Gastritis; Gastroduodenal ulcer; Gastric cancer; Myeloperoxidase; H pylori