Published online Feb 21, 2007. doi: 10.3748/wjg.v13.i7.1119
Revised: December 3, 2006
Accepted: January 23, 2007
Published online: February 21, 2007
AIM: To study whether H pylori are associated with chronic cholecystitis.
METHODS: The subjects were divided into three groups: H pylori-infected cholecystitis group, H pylori-negative cholecystitis group and control group. Pathologic changes of the gallbladder were observed by optic and electronic microscopes and the levels of interleukin-1, 6 and 8 (IL-1, 6 and 8) were detected by radioimmunoassay.
RESULTS: Histological evidence of chronic cholecystitis including degeneration, necrosis, inflammatory cell infiltration, were found in the region where H pylori colonized. Levels of IL-1, 6 and 8 in gallbladder mucosa homogenates were significantly higher in H pylori-infected cholecystitis group than those in H pylori-negative cholecystitis group and control group.
CONCLUSION: H pylori infection may be related to cholecystitis.