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©2007 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2007; 13(47): 6344-6346
Published online Dec 21, 2007. doi: 10.3748/wjg.v13.i47.6344
Published online Dec 21, 2007. doi: 10.3748/wjg.v13.i47.6344
Pancreatic endocrine and exocrine changes in celiac disease
Hugh J Freeman, Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Hugh J Freeman, MD, FRCPC, FACP, Gastroenterology, UBC Hospital, 2211 Wesbrook Mall, Vancouver, BC, V6T 1W8, Canada. hugfree@shaw.ca
Telephone: +1-604-8227216 Fax: +1-604-8227236
Received: June 15, 2007
Revised: July 16, 2007
Accepted: November 22, 2007
Published online: December 21, 2007
Revised: July 16, 2007
Accepted: November 22, 2007
Published online: December 21, 2007
Abstract
Although there is a great deal of information on celiac disease and associated involvement of other non-intestinal sites, data on concomitant changes in the structure and function of the pancreas is limited. The present review critically examines pancreatic endocrine changes that have been well documented in the literature, including insulin-dependent diabetes mellitus. Pancreatic exocrine alterations may also occur, and if severe, marked malnutrition with pancreatic failure and ductal calcification have been observed. Finally, other pancreatic disorders have been recorded with celiac disease.
Keywords: Celiac disease; Gluten-sensitive enteropathy; Diabetes mellitus; Chronic pancreatitis; Pancreatic function