Epidermal growth factor receptor antibody plus recombinant human endostatin in treatment of hepatic metastases after remnant gastric cancer resection

doi:10.3748/wjg.v13.i45.6115

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Dec 7, 2007 (publication date) through Nov 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2007; 13(45): 6115-6118
Published online Dec 7, 2007. doi: 10.3748/wjg.v13.i45.6115

Epidermal growth factor receptor antibody plus recombinant human endostatin in treatment of hepatic metastases after remnant gastric cancer resection

Long Sun, Huang-Yang Ye, Ying-Hong Zhang, Yong-Song Guan, Hua Wu

Long Sun, Hua Wu, Minnan PET Center, The First Hospital of Xiamen, Fujian Medical University, Xiamen 316003, Fujian Province, China

Huang-Yang Ye, Ying-Hong Zhang, Department of Oncology, The First Hospital of Xiamen, Fujian Medical University, Xiamen 316003, Fujian Province, China

Yong-Song Guan, State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, Chengdu 610041, Sichuan Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Hua Wu, Minnan PET Center, The First Hospital of Xiamen, Fujian Medical University, Xiamen 316003, Fujian Province, China. wuhua1025@163.com

Telephone: +86-592-2139527 Fax: +86-592-2139527

Received: July 31, 2007
Revised: September 5, 2007
Accepted: October 26, 2007
Published online: December 7, 2007

Abstract

We report a 55-year-old male who developed advanced hepatic metastasis and peritoneal carcinomatosis after resection of remnant gastric cancer resection 3 mo ago. The patient only received epidermal growth factor (EGF) receptor antibody (Cetuximab) plus recombinant human endostatin (Endostar). Anti-tumor activity was assessed by ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computer tomography (PET/CT) at baseline and then every 4 wk. The case illustrates that ¹⁸FDG-PET/CT could make an early prediction of the response to Cetuximab plus Endostar in such clinical situations. ¹⁸FDG-PET/CT is a useful molecular imaging modality to evaluate the biological response advanced hepatic metastasis and peritoneal carcinomatosis to Cetuximab plus Endostar in patients after remnant gastric cancer resection.

Keywords: Hepatic metastasis; Remnant gastric cancer; Cetuximab; Recombinant human endostatin; ¹⁸F-fluorodeoxyglucose; Positron emission tomography/computer tomography