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World J Gastroenterol. Sep 14, 2007; 13(34): 4589-4592
Published online Sep 14, 2007. doi: 10.3748/wjg.v13.i34.4589
Gastrectomy for patients with gastric cancer and non-uremic renal failure
Shozo Mori, Tokihiko Sawada, Kiyoshige Hamada, Junji Kita, Mitsugi Shimoda, Nobumi Tagaya, Keiichi Kubota
Shozo Mori, Tokihiko Sawada, Kiyoshige Hamada, Junji Kita, Mitsugi Shimoda, Nobumi Tagaya, Keiichi Kubota, Second Department of Surgery, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321-0293, Japan
Author contributions: All authors contributed equally to the work.
Correspondence to: Tokihiko Sawada, MD, PhD, Second Department of Surgery, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321-0293, Japan. tsawada@dokkyomed.ac.jp
Telephone: +81-282-872158 Fax: +81-282-866317
Received: May 21, 2007
Revised: June 2, 2007
Accepted: June 9, 2007
Published online: September 14, 2007
Abstract

AIM: To investigate the safety and outcome of gastrectomy for patients with gastric cancer and non-uremic renal failure (NURF).

METHODS: One hundred forty-seven patients who underwent gastrectomy for carcinoma were retrospectively divided into two groups: a group with Ccr values of ≥ 50 mL/min (Group 1; n = 110), and one with Ccr values of ≥ 20 to < 50 mL/min (Group 2; n = 37). Preoperative patient characteristics, intraoperative parameters (including operation time and blood loss), and postoperative management and complications were evaluated.

RESULTS: There were no statistically significant differences between the two groups in operation time (297.9 min vs 272.6 min, P = 0.137) or blood loss (435 mL vs 428 mL, P = 0.078). The differences in postoperative complications and hospital stay between the groups were not statistically significant. None of the patients in Group 2 required dialysis therapy, and no patients died due to gastrectomy or gastrectomy-related causes. The overall 4-year survival rates in Groups 1 and 2 were 86.6% and 81.8%, respectively (P = 0.48), and the corresponding 4-year disease-free survival rates for stageI, II, and III patients were 88.7% and 83.5%, respectively (P = 0.65).

CONCLUSION: Gastrectomy can be performed as safely in patients with NURF similar to patients with normal renal function.

Keywords: Gastric cancer; Non-uremic renal failure; Gastrectomy; Chronic kidney disease