Harder H, Büchler MW, Fröhlich B, Ströbel P, Bergmann F, Neff W, Singer MV. Extrapulmonary sarcoidosis of liver and pancreas: A case report and review of literature. World J Gastroenterol 2007; 13(17): 2504-2509 [PMID: 17552036 DOI: 10.3748/wjg.v13.i17.2504]
Corresponding Author of This Article
Manfred V Singer, MD, Professor of Medicine and Chairman, Department of Medicine II(Gastroenterology, Hepatology and Infectious Diseases), University Hospital of Heidelberg at Mannheim, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany. manfred.v.singer@med.ma.uni-heidelberg.de
Article-Type of This Article
Case Report
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World J Gastroenterol. May 7, 2007; 13(17): 2504-2509 Published online May 7, 2007. doi: 10.3748/wjg.v13.i17.2504
Extrapulmonary sarcoidosis of liver and pancreas: A case report and review of literature
Hermann Harder, Markus W Büchler, Boris Fröhlich, Philipp Ströbel, Frank Bergmann, Wolfgang Neff, Manfred V Singer
Hermann Harder, Manfred V Singer, Department of Medicine II (Gastroenterology, Hepatology and Infectious Diseases), University Hospital of Heidelberg at Mannheim, Germany
Philipp Ströbel, Institute of Pathology, University Hospital of Heidelberg at Mannheim, Germany
Wolfgang Neff, Institute of Radiology, University Hospital of Heidelberg at Mannheim, Germany
Markus W Büchler, Boris Fröhlich, Department of Surgery, University of Heidelberg, Germany
Frank Bergmann, Institute of Pathology, University of Heidelberg, Germany
Author contributions: All authors contributed equally to the work.
Correspondence to: Manfred V Singer, MD, Professor of Medicine and Chairman, Department of Medicine II(Gastroenterology, Hepatology and Infectious Diseases), University Hospital of Heidelberg at Mannheim, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany. manfred.v.singer@med.ma.uni-heidelberg.de
Telephone: +49-621-3833284 Fax: +49-621-3833805
Received: November 23, 2006 Revised: November 28, 2006 Accepted: February 8, 2007 Published online: May 7, 2007
Abstract
Sarcoidosis is a chronic multisystemic granulomatous disease of unknown origin, which can involve nearly all organs. In the case of an infrequent gastrointestinal tract involvement in systemic sarcoidosis, granulomas of the liver are most commonly described while isolated pancreatic sarcoid lesions are rarely seen. We report a case of systemic sarcoidosis with exclusive extrapulmonal involvement of the liver and the pancreas in a 71-year-old white man. The diagnosis of liver involvement was confirmed by biopsy. Pancreatic surgery was needed because preoperative evaluation could not exclude pancreatic cancer and for biliary decompression. An extensive literature review of systemic sarcoidosis, focusing on reported cases with unusual presentation of sarcoidosis in the liver and the pancreas, its diagnosis, treatment, and prognosis was made.
