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©2007 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jan 7, 2007; 13(1): 1-7
Published online Jan 7, 2007. doi: 10.3748/wjg.v13.i1.1
Published online Jan 7, 2007. doi: 10.3748/wjg.v13.i1.1
Nutritional modulation of the inflammatory response in inflammatory bowel disease- From the molecular to the integrative to the clinical
Gary E Wild, Department of Medicine, Division of Gastroenterology, McGill University, Montreal, Quebec; Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
Laurie Drozdowski, Alan BR Thomson, Division of Gastro-enterology, University of Alberta, Edmonton, Alberta, Canada
Carmela Tartaglia, Department of Physiology, McGill University, Montreal, Quebec, Canada
M Tom Clandinin, Department of Agriculture, Foods and Nutrition, University of Alberta, Edmonton, Alberta, Canada
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Alan BR Thomson, Zeidler Ledcor Center, 130, University Campus, Edmonton, AB T6G 2X8, Canada. alan.thomson@ualberta.ca
Telephone: +1-780-4926490 Fax: +1-780-4927964
Received: July 30, 2006
Revised: September 7, 2006
Accepted: October 5, 2006
Published online: January 7, 2007
Revised: September 7, 2006
Accepted: October 5, 2006
Published online: January 7, 2007
Abstract
Nutrient deficiencies are common in patients with inflammatory bowel disease (IBD). Both total parenteral and enteral nutrition provide important supportive therapy for IBD patients, but in adults these are not useful for primary therapy. Dietary intervention with omega-3 polyunsaturated fatty acids contained in fish oil may be useful for the care of IBD patients, and recent studies have stressed the role of PPAR on NFκB activity on the potential beneficial effect of dietary lipids on intestinal function.
Keywords: Crohn’s disease; Ulcerative colitis; Enteral nutrition; Parenteral nutrition; Glutamine; Fiber; Long chain fatty acids