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World J Gastroenterol. Dec 7, 2006; 12(45): 7388-7390
Published online Dec 7, 2006. doi: 10.3748/wjg.v12.i45.7388
Expression of semaphorin 6D in gastric carcinoma and its significance
Xiang-Yang Zhao, Lin Chen, Qian Xu, Yu-Hong Li
Xiang-Yang Zhao, Lin Chen, Department of General Surgery, General Hospital of Chinese PLA, Beijing 100853, China
Qian Xu, Institute of Basic Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China
Yu-Hong Li, Department of Pathology, Chengde Medical College, Chende 067000, Hebei Province, China
Correspondence to: Professor Lin Chen, Department of General Surgery, General Hospital of Chinese PLA, 28 Fuxing Road, Beijing 100853, China. chenlinbj@vip.sina.com
Telephone: +86-10-66937846 Fax: +86-10-68181689
Received: September 1, 2006
Revised: September 28, 2006
Accepted: October 25, 2006
Published online: December 7, 2006
Abstract

AIM: To investigate the protein and mRNA expression of semaphorin 6D in gastric carcinoma and its significance.

METHODS: The protein and mRNA expression of semaphorin 6D was detected by semi-quantitative rever-se transcription PCR and Western blotting respectively in 30 cases of gastric carcinoma and normal gastric mucosa.

RESULTS: The protein and mRNA expression of semaphorin 6D in gastric carcinoma was significantly higher than that in normal gastric mucosa (0.24 ± 0.06 vs 0.19 ± 0.07, 0.26 ± 0.09 vs 0.20 ± 0.10, P < 0.05).

CONCLUSION: Semaphorin 6D may play an important role in the occurrence and development of gastric carcinoma, and is related to tumor angiogenesis.

Keywords: Semaphorin 6D; Gastric carcinoma; Normal gastric mucosa; Angiogenesis